The Study Of The Effect Of EA Combined With Heavy-Moxibustion On Analgesic Effect And T Cell On Acute Herpes Zoster

Objective : By randomized controlled trail(RCT),to compare the clinical effect,analgesic effect and the incidence of PHN with EA combined with heavy-moxibustion and Western Medicine,and to explore the relationship between the progress of herpes zoster and T cell subsets.Methods:There are 72 cases with acute herpes zoster were selected from 2015 June to August 2016,and two of them are konckedout.The treatment group was treated with EA combined with heavy-moxibustion,and the cntrol group treated with western medicine.We evaluated the symptom score and pain score during the course of treatment,and observed the changes of T cell subsets of subjects before and after treatment,and followed up at the end of treatment.Results:(1)Baseline comparison: There was no significant difference between the two groups in baseline condition(P<0.05).And the two group could observe comparable.(2)Comprehensive effect comparison: The treatment group had significant difference compared with the control group in therapeutic index and symptom scores(P<0.05).There was no significant difference between the two groups in comprehensive efficacy evaluation(P>0.05).(3)Comparison of pain index:There was significant difference between the two groups in VAS score,pain onset time and duration of pain after treatment(P<0.05).(4)Herpes index:There was significant difference between the time of callus removal(P<0.05),but nosignificant difference was found between the time of stopping blister and the time of scab(P>0.05).(5)Comparison of T cell subsets:Comparison between groups: The difference between the treatment group and the control group was has statistically significant in T cell subsets(P<0.05).Comparison of intra-group: After treatment,the levels of T cell subsets in two groups compared with before treatment,the difference was statistically significant(P<0.05).(6)The occurrence rate of PHN:The difference between the two groups was statistically significant(P<0.05)after the follow-up of thirtieth days,sixtieth days and ninetieth days.(7)Safety and tolerability evaluation:The two groups are safe and effective with good acceptability and tolerance.Conclusion:(1)The effect of EA combined with heavy-moxibustion therapy on herpes zoster is exact.The therapy is easy to be popularized and applied in clinic.(2)There is a correlation between the progression of herpes zoster and T cell subsets.The early regulation of cellular immune function can shorten the course of disease and reduce the incidence of PHN.