Analysis Of The Whole Brain Volume In Premature Infants At Full Term Of Corrected Gestational Age

Objective:Measuring the whole brain volume in premature infants at 37 ~ 40 weeks of corrected gestational age.Analysis and Visualization.To compare and analyze the difference of whole brain volume between preterm infants at term and normal term infants,and to evaluate the brain development of premature infants at term.The risk factors related to the size of the whole brain volume were analyzed retrospectively.Methods:From September 2015 to January 2018,preterm infants with gestational age less than 32 weeks and birth weight less than 1500 g who were in the neonatal intensive care unit of the First Affiliated Hospital of Jinan University were selected as the research subjects.At 37 ~ 40 weeks of corrected gestational age,the MRI images were collected.The whole brain volume was measured by VOI toolbox of MIPAV software and compared with that of normal term infants.To collecting The clinical data of these preterm infants,including gestational age,birth weight,body length,head circumference,sex,single or multiple pregnancy,Apgar score,intrauterine growth restriction,intrauterine distress,child-bearing age,illness during pregnancy(hypertension,diabetes,thyroid dysfunction),invasive mechanical ventilation,early onset sepsis,chronic lung disease,Patent ductus arteriosus,prenatal and postnatal hormone use,and analyzing the relationship between these factors and whole brain volume in premature infants at 37 ~ 40 weeks of corrected gestational age.Results:1.The whole brain volume of premature infants at 37 ~ 40 weeks of corrected gestational age(311.71±25.35ml)was smaller than that of normal term infants(339.44±18.82ml).The difference was statistically significant(P<0.05).2.The results of single factor analysis showed that gestational age,birth weight,IUGR,Apgar score at one minute after birth less than or equal to 7 points,invasive mechanical ventilation and duration of ventilation,shock,pulmonary hemorrhage,early onset sepsis,chronic lung disease,postnatal hormone use of DXMT and cerebral injury are risk factors for reduction of whole brain volume at term in preterm infants(P<0.05).3.The results of multivariate Logistic regression analysis showed that gestational age,IUGR,Apgar score at one minute after birth less than or equal to 7 points,duration of invasive mechanical ventilation and early onset sepsis were the independent risk factors for reduction of whole brain volume at term in premature infants(P<0.05).Conclusion:1.Magnetic resonance imaging combined with MIPAV software can be used to measure the whole brain volume of newborns.It was feasible and repeatable.2.The whole brain volume of premature infants at 37 ~ 40 weeks of corrected gestational age was lower than that of normal term infants with matched gestational age.The brain development of preterm infants at term was behind that of normal term infants.3.The reduction of whole brain volume at term in preterm infants was influenced by many factors,such as gestational age,birth weight,IUGR,Apgar score at one minute after birth less than or equal to 7 points,invasive mechanical ventilation and duration of ventilation,shock,pulmonary hemorrhage,early onset sepsis,chronic lung disease,postnatal hormone use of DXMT and cerebral injury.Comprehensive measures should be taken to prevent its occurrence.4.Gestational age,IUGR,Apgar score at one minute after birth less than or equal to 7 points,duration of invasive mechanical ventilation and early onset sepsis were the independent risk factors for reduction of whole brain volume at term in premature infants.