Application Of The Fractional Exhaled Nitric Oxide And Percentage Of Peripheral Blood Eosinophils In Diagnosis Of Bronchiectasis Accompanied With Asthma

Objective:To investigate the expression level and clinical significance of Fractional exhaled Nitric Oxide and Percentage of eosinophils in peripheral blood in the diagnosis of Bronchiectasis accompanied with asthma.Methods:From September 2016 to June2017,in the Section of Respiratory of the attached Hospital of Shihezi Collage,All patients is divided into Bronchiectasis accompanied with asthma37 cases,Bronchiectasis no asthma 36 cases,and Asthma no bronchiectasis 37 cases,while 25 cases healthy people were selected as normal control group.All patients were tested FENO and EOS% level and compared clinical manifestations of each group.Results:(1)Bronchiectasis accompanied with asthma group had a high incidence rate in personal allergic history and pulmonary auscultation and wheeze,were 20(54.19%)and 28(75.77%),while Bronchiectasis group were 5(14.78%)and 6(16.76%),the difference was statistically significant(P<0.05).Asthma group had a high incidence rate than Bronchiectasis group in personal allergic history and pulmonary auscultation and wheeze were 18(48.68%)and 26(70.30%).(2)Comparison of pulmonary function before bronchial dilatation.In Bronchiectasis no asthma group,FEV1,FEV1(%),FEVI/FVC(%),MMEF(%)were no different from those of normal control group.In Bronchiectasis with asthma,FEV1,FEV1(%),FEVI/FVC(%),MMEF(%)were significantly different from those of Bronchiectasis group(P<0.05).(3)It was the same in FENO and peripheral blood EOS% levels between the Bronchiectasis group and the normal control group(P>0.05).Bronchiectasis accompanied with asthma group FENO(59.51±29.63)ppb,EOS(6.34±4.20)% was significantly higher than that of Bronchiectasis group FENO(12.36±7.28)ppb EOS level(1.73±1.31)% and normal control group FENO(15.68±6.68)ppb and EOS(0.69±0.74)%,P<0.05.Further correlation analysis showed that there was a positive correlation between FENO and peripheral blood EOS%(r=0.583,P<0.05)in Bronchiectasis and asthma group.Conclusion:The expression of FENO and EOS% in peripheral blood was significantly higher in patients with Bronchiectasis complicated with asthma.FENO and EOS% may be of important reference value in the diagnosis of Bronchiectasis accompanied with asthma.