Association Between IL-10-1082G/A Gene Polymorphism And Susceptibility Of Recurrent Oral Ulcer:A Meta-analysis

PURPOSE : To systematically review the association between interleukin-10(IL-10)-1082G/A gene polymorphism and susceptibility of recurrent oral ulcer(ROU)by a meta-analysis.METHODS:Databases of PubMed,Embase,Web of Science,CNKI,CBM,Wanfang,and VIP were electronically searched to collect studies published up to August 2017 about the association between IL-10-1082G/A gene polymorphism and ROU susceptibility.According to the inclusion and exclusion criteria,two reviewers independently screened literature and extracted data,the methodological quality assessment and heterogeneity test of included studies were performed.Meta-analysis was performed by RevMan5.3 software.RESULTS:A total of 6 case-control studies were included,which involved 668 ROU patients in case group and 769 healthy individuals in control group.In the general population,the results of meta-analysis showed that,under 3 genetic models including allele model(G vs A),recessive model(GG + GA vs AA)and heterozygous model(GA vs AA),there was signifcant association between IL-10-1082G/A gene polymorphism and ROU susceptibility(G vs A: OR = 1.31,95% CI 1.03 to 1.66,P = 0.03;GG + GA vs AA: OR = 1.45,95% CI 1.16 to 1.82,P = 0.001;GA vs AA: OR = 1.33,95% CI 1.04 to 1.70,P = 0.02).In the Asian population,meta analysis result was consistent with the general population.CONCLUSION:IL-10-1082G/A gene polymorphism is associated with ROU susceptibility.Individuals with G allele and GA genotype have a higher risk of ROU.Future more well-designed,large sample and multicenter studies are greatly needed to verify our conclusion.