The Cerebral Palsy Risk Caused By Hyperbilirubinemia:A Systematic Review And Meta-analysis

Objective: Cerebral palsy is a group of non-progressive motor and postural disorders.Preterm birth,asphyxia anoxia,severe infection,Severe hyperbilirubinemia are high risk factors of cerebral palsy,and Rh hemolytic disease,system ABO hemolytic disease,Preterm birth and low birth weight are the main causes of severe high blood bilirubin,many studies suggest that serum bilirubin level more than 325?mol/L will increase the incidence of cerebral palsy.To reduce the potential of high bilirubin neurotoxicity in time,in 2004 the American academy of pediatrics suggest STB 342 ?mol/L or more or STB 428 ?mol/Lor more need to exchange transfusion.Researches about whether the bilirubin level increases the risk of cerebral palsy is scattered and controversial,this study aims to evaluate STB at higher than 325 ?mol/L whether to increase the incidence of cerebral palsy.To provide evidence-based for the clinical treatment of hyperbilirubinemia.Methods:The Medline(1963 to Oct.2016),Embase(1963 to Oct.2016),C-NKI(1911 to Oct.2016),Wanfang database(1998 to Oct.2016),VIP(1989 to Oct.2016)were searched to identify cohort studies which assessing the risk of cerebral palsy of hyperbilirubinemia.The quality of the included studies was assessed by the Newcastle Ottawa Scale(NOS),RevMan5.0 was used for met aanalysis.Results:Two studies were included(n=162568),the quality of the rese arches is h-igher.the risk of cerebral palsy for the exposed group(STB?325 ?mol/L)is greater than the one(STB < 325 umol/L)significantly,(OR=3.87,95% CI:1.85 ~ 8.09),this difference is statistically significant.Conclusion:The risk of cerebral palsy for patients with STB?325?m ol/L will in crease.However,whether the treatment can reduce the risk rem ains need to be verified by prospective of non randomized controlled study.