Dysbiosis Of Gut Microbiota Can Increase The Risk Of Stroke

Cerebrovascular disease has become the leading cause of death among Chinese residents in recent decades.Accumulating evidence has demonstrated that dysbiosis of intestinal microbiota is closely linked to stroke.Hypertension,dyslipidemia,diabetes which are the risk factors of stroke also have a strong relationship with imbalanced microbiota.Additionally,gut microbiota participates in the process of atherosclerosis and thrombosis,ultimately affecting the aetiopathogenesis of cerebrovascular disease.Gut microbiota-producing metabolites,including short chain fatty acids,and trimethylamine-N-oxide,as well as the bacteria-derived lipopolysaccharide and peptidoglycan play a vital role in aetiopathogenesis of stroke.Therefore,targeting gut microbiota may be a novel therapeutic strategy for prevention and treatment of metabolic disorders and stroke.There exist various approaches that target microbiota,including fecal transplantation,antibiotics,probiotics,prebiotics and traditional Chinese herbs.The emergence of these new therapeutic approaches has led to renewed interest in exploring the potential role of gut microbiota as an alternative therapeutic strategy to combat chronic metabolic disorders,especially cerebrovascular diseases.