Clinical Investigation Of The Influence Of PM2.5 On ACO Patients In Shijiazhuang Area

Objective:A clinical investigation of ACO patients in Shijiazhuang haze area of Hebei province.Analyze the influence of haze on ACO patients.Methods:1.Collected the daily air quality index(AQI)-PM2.5 data of Shijiazhuang from January 2017 to January 2018.2.Collected patients with chronic obstructive pulmonary disease(hereinafter referred to as COPD)and patients with bronchial asthma from January 2017 to January 2018 in the respiratory medicine department of The Second Hospital of Hebei Medical University..ACO patients were selected for clinical investigation.3.Draw the number of cases of ACO patients in the month-haze month PM2.5 mean-month polygon chart.4.Draw a quarterly ACO patient cough score-quarterly PM2.5 mean broken line chart.5.Analysis of blood routine EO%in four groups of patients.Results:1.In patients with COPD(acute exacerbation),there were more males than females,more females with asthma than males,and more males with ACO than females.In patients with COPD(acute exacerbation),the proportion of male patients with asthma and ACO was significantly higher(P<0.001),and the ACO patients were more male than those with asthma(P<0.001).2.The ACO constitute 17%of patients in hospitalized COPD(acute exacerbation)and asthma patients(P=0.005),in hospitalized patients with acute aggravating period of COPD pathogenesis composition ratio is 22.5%(P<0.01),the onset of asthma patients in hospital the proportion is as high as 40%(P= 0.001)3.There was a significant correlation between the incidence of simple COPD(acute exacerbation)and PM2.5(P<0.05),and ACO had a certain correlation with PM2.5,and the correlation between the incidence of simple asthma and PM2.5 was not obvious.4.The cough quantification score of ACO patients was significantly correlated with PM2.5.5.Simple asthma,the ACO group routine blood EO%average more than 2.0%(P<0.05),and simple COPD group and healthy control group routine blood EO%average less than 2.0%(P<0.05),of which the ACO group routine blood EO%average of 3.92%,more than 3.21%of the simple asthma group.The EO%(3.98 + 0.046)in group ACO was significantly higher than that in the simple COPD group(1.12 + 0.015)and the healthy control group(0.78+0.014).The difference was statistically significant(P<0.05),and was higher than that of the simple asthma group(3.21 + 0.040),and the difference was not statistically significant(P>0.05).Conclusion:1.There were significant differences in gender composition in hospitalized patients with COPD(acute exacerbation),asthma and ACO.2.The incidence composition of ACO patients in hospitalized patients with COPD(acute exacerbation)was lower than that in asthma.3.To a certain extent,PM2.5 will aggravate the incidence of ACO patients.4.PM2.5 will aggravate the attack degree of cough in ACO patients.5.There is a significant difference in the EO%mean level between ACO patients and simple COPD(acute exacerbation)and healthy adults.