Study The Correlation Between Level Of Fractional Exhaled Nitric And Serum IL-17 In Patients With Primary Bronchial Asthma

Objective: To detect the different levels of serum IL-17 and FeNO in asthmatic patients and to explore the correlation between these two kinds of airway inflammation markers and lung function injury and obesity,and to evaluate the role of IL-17 and FeNO in the phenotype classification of bronchial asthma.Methods:Sixty-six cases of preliminary diagnosed asthma in the second hospital of Hebei province in March 2016 to May 2017,were randomly divided into three groups according to FeNO level,that is:low,middle and high FeNO group.The serum concentration of IL-17,lung function and body mass index(BMI)were recorded in addition to the FeNO level.At the same time,twelve cases were selected as the healthy control group.Results:1.The concentration of serum IL-17 in the asthmatic group was higher than that of the control group(P<0.05),and the concentration of serum IL-17 in the high group was higher than that of the control group(P<0.05).2.Compared between three groups of asthma,the concentration of serum IL-17 in the media group was higher than that of the high group(P<0.05),and there was no significant difference between the remaining groups(P>0.05).3.FEV1/pred in the high group of asthma was significantly larger than that in the median group(P<0.05),there was no significant difference between the other groups(P>0.05),there was no significant difference in MEF50/pred between the three groups(P>0.05).4.There was a positive correlation between the level of FeNO in three groups of asthma and serum IL-17(P<0.05),and the difference was statistically significant.There was no correlation between two indexes in eachgroup(P>0.05).5.There was no correlation between serum IL-17 concentration and FEV1/pred and MEF50/pred in three groups of asthma,but the difference was not statistically significant(P>0.05),but IL-17 in the median group was positively correlated with FEV1/pred(P<0.05).6.There was a positive correlation between FeNO level and MEF50/pred(P<0.05)in three groups of asthma(P<0.05),and no correlation with FEV1/pred(P>0.05).7.There was no correlation between FeNO level,serum IL-17 concentration and body mass index in three groups of asthma(P>0.05).Conclusion:The serum levels of IL-17 and FeNO in the patients with asthma were increased,and the IL-17 in the high group was not significantly elevated.There is no significant correlation between FeNO and IL-17.It is suggested that Fe NO and IL-7 represent different inflammatory processes,and our results are helpful in further phenotype research of asthma.