Analysis Of Thrombolytic Status Of Stroke And The Clinical Prognosis Of Different Therapy In Hebei Province

Objective: We sought to assess thrombolysis status in different grades hospitals in Hebei Province and try to analyze the clinical prognosis of different therapy in patients with acute ischemic stroke.Methods:We prospective investigation patients with acute ischemic stroke admission to the emergency department between January 2016 and December 2016 in 49 hospitals from Hebei Province.Patients were divided into thrombolysis group and non-thrombolysis group.The clinical outcomes were measured by the Glasgow Outcome Scale(GOS).The thrombolytic situation and the ratio of good prognosis at discharge(GOS 4-5)compared between separate grade hospitals and different therapy.Results: A total of 3558 acute ischemic stroke patients were collected,among them 2549 patients from Tertiary Hospital and 1009 patients from Secondary Hospital.Of these,only 419(11.78%)of acute ischemic stroke patients received thrombolytic therapy(Standard thrombolysis,n=216,Non-standard thrombolysis,n=203)and 3139 received conservative therapy.A total of 384 patients in the thrombolysis group achieved favorable outcomes(GOS 4-5)at discharge.Among them 204 patients received standard thrombolysis,and 180 patients received non-standard thrombolysis.The thrombolysis group achieved more favorable outcomes(GOS 4-5)at discharge than conservative treatment group(P<0.05).Further discovery that the rate of favorable outcomes was significantly higher in the standard thrombolysis than the non-standard thrombolysis(P < 0.05).In Tertiary Hospital,12.95% patients received thrombolytic therapy whereas only 8.82% patients in Secondary Hospital(P<0.05).In Tertiary Hospital,86.47% patients achieved more favorable outcomes(GOS 4-5)at discharge than 74.73%in Secondary Hospital(P<0.05).Conclusion:Compared to the national average,there was a higher thrombolysis therapy rate in Hebei Province.Thrombolysis therapy achieved more favorable outcomes than conservative treatment therapy.Tertiary Hospital had more advantage than Secondary Hospital in the Thrombolysis therapy rate and clinical prognosis.Standard thrombolysis could enhance the prognosis of patients with acute ischemic stroke.