Effect Of Dexmedetomidine On Oxygen Free Radical In Severe Burn Patients Peri Anesthesia Period

Objective: To observe the effect of dexmedetomidine in severe burn patients peri anesthesia of oxygen free radical related indexes(PLO,NO,OH,SOD,GSH-Px,MDA,AOPP),analysis of protective effect of dexmedetomidine in severe burn patients with ischemia reperfusion injury.Methods: a total of 92 patients with severe burn treated in 2017 1-5 were randomly divided into experimental group(46 cases)and control group(46cases).The experimental group was treated with dexmedetomidine induction and maintenance were the same in two groups.Induction with Fentanyl3-5ug/kg,Etomidate0.2mg/kg,Cisatracrium Besilate0.2mg/kg,anesthesia maintenance with the same Propofol and Remifentanil in two groups.In the experimental group,dexmedetomidine was stopped before anesthesia was over.The changes of vital signs were monitored at four time points: 1 min before intubation,1 min after intubation,1 min after skin incision and 1 min after extubation,and the related indexes of serum oxygen free radicals(PLO,NO,OH,SOD,GSH-Px,MDA,AOPP)were detected.Results: The vital signs were stable in both groups,and there was no significant difference between the two groups(P>0.05).PLO,NO,OH,SOD,GSH-Px,MDA and AOPP were not statistically significant at baseline,PLO,NO,OH,MDA and AOPP were significantly lower and SOD,GSH-Px were significantly higher than that in the control group(P>0.05)in 1 min after intubation,1 min after skin incision and 1 min after extubation three time points.and there were statistically significant in groups and between groups(P<0.05).Conclusion: Dexmedetomidine can effectively reduce the levels of oxygen free radicals PLO,NO and OH,raise SOD,GSH-Px,reduce the products of MDA and AOPP,thus effectively prevent oxygen free radicals attacking the tissues of severe burn patients,and the same time reduce lipid peroxidation,and prevent ischemic reperfusion injury.