Quantitative Study On Pulmonary Small Vessel Volume Of COPD Based On HRCT

Part?MATERIALS and METHODS:In accordance with inclusion and exclusion criteria 62 COPD Patients as experimental group and 92 healthy persons as contrast group were included?Automatic measuring small vessel volume in expiration and in inspiration include whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe between COPD Patients and healthy persons base on the platform of FACT-Digital lung^TM?small vessel volume in expiration and in inspiration were compared between COPD Patients and healthy persons using Independent sample T test?RESULTS:?1?Inspiration:small vessel volume in whole lung?right lung?left lung?right upper lobe?right lower lobe?left upper lobe and left right lower lobe between COPD Patients and healthy persons had statistical difference?respectively,P=0.000?0.000?0.000?0.000?0.000?0.000 and0.000?,right middle lobe had not statistical difference;?2?Expiration:small vessel volume in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe between COPD Patients and healthy persons had statistical difference?respectively,P=0.000?0.000?0.000?0.000?0.032?0.000?0.000and 0.000??CONCLUSION:Except right middle lobe no statistical difference in inspiration,small vessel volume in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe between COPD Patients and healthy persons had statistical difference?The anatomical variability of the right middle lobe and lacking collateral ventilation leaded to this experimental result?From this result,it can be concluded that the experimental method has a certain value in the evaluation of pulmonary small left lung vessel disease?Part?MATERIALS and METHODS:In accordance with inclusion and exclusion criteria 62 COPD Patients were included?Automatic measuring small vessel volume in expiration?small vessel volume in inspiration?LAA-950 in inspiration and LAA-910 in expiration include whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe of COPD Patients based on the platform of FACT-Digital lung^TM?Both the relationship between small vessel volume and LAA-950 in inspiration and the relationship between small vessel volume and LAA-910in expiration were used Pearson's correlation analysis?RESULTS:?1?The relationship between small vessel volume and LAA-950in inspiration:small vessel volume in whole lung was moderate positive correlated with LAA-950 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe and left upper lobe?respectively,r=0.576,P=0.000;r=0.622,P=0.000;r=0.499,P=0.000;r=0.540,P=0.000;r=0.455,P=0.000;r=0.509,P=0.000;r=0.496,P=0.000?,small vessel volume in whole lung was mild positive correlated with LAA-950 in left lower lobe?r=0.398,P=0.001?;small vessel volume in right lung was moderate positive correlated with LAA-950 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.587,P=0.000;r=0.619,P=0.000;r=0.525,P=0.000;r=0.551,P=0.000;r=0.447,P=0.000;r=0.497,P=0.000;r=0.531,P=0.000;r=0.410,P=0.001?;small vessel volume in left lung was moderate positive correlated with LAA-950 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe and left upper lobe?respectively,r=0.526,P=0.000;r=0.581,P=0.000;r=0.440,P=0.000;r=0.493,P=0.000;r=0.431,P=0.000;r=0.485,P=0.000;r=0.429,P=0.000?,small vessel volume in left lung was mild positive correlated with LAA-950 in left lower lobe?r=0.360,P=0.004?;small vessel volume in right upper lobe was moderate positive correlated with LAA-950 in right upper lobe?r=0.427,P=0.001;?,small vessel volume in right upper lobe was mild positive correlated with LAA-950 in right lung and left upper lobe?respectively,r=0.622,P=0.000;r=0.499,P=0.000?;small vessel volume in right middle lobe was moderate positive correlated with LAA-950 in whole lung?right lung and right middle lobe?respectively,r=0.410,P=0.001;r=0.432,P=0.000;r=0.530,P=0.000?,small vessel volume in right middle lobe was mild positive correlated with LAA-950 in left lung?right upper lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.367,P=0.003;r=0.338,P=0.007;r=0.310,P=0.014;r=0.337,P=0.007;r=0.321,P=0.011?;small vessel volume in right lower lobe was moderate positive correlated with LAA-950 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.631,P=0.000;r=0.630,P=0.000;r=0.605,P=0.000;r=0.430,P=0.000;r=0.487,P=0.000;r=0.619,P=0.000;r=0.496,P=0.000;r=0.587,P=0.000?;small vessel volume in left upper lobe was moderate positive correlated with LAA-950 in right lung and right upper lobe?respectively,r=0.463,P=0.000;r=0.464,P=0.000;?,small vessel volume in left upper lobe was mild positive correlated with LAA-950 in whole lung?left lung?right middle lobe?right lower lobe?left upper lobe?respectively,r=0.387,P=0.002;r=0.284,P=0.025;r=0.320,P=0.011;r=0.326,P=0.010;r=0.376,P=0.003?;small vessel volume in left lower lobe was moderate positive correlated with LAA-950 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe and left lower lobe?respectively,r=0.544,P=0.000;r=0.570,P=0.000;r=0.489,P=0.000;r=0.421,P=0.001;r=0.443,P=0.000;r=0.529,P=0.000;r=0.484,P=0.000?,small vessel volume in left lower lobe was mild positive correlated with LAA-950 in left upper lobe?r=0.392,P=0.002???2?The relationship between small vessel volume and LAA-950 in expiration:small vessel volume in whole lung was highly positive correlated with LAA-910 in whole lung and right lung?respectively,r=0.720,P=0.000;r=0.715,P=0.000?,small vessel volume in whole lung was moderate positive correlated with LAA-910 in left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.697,P=0.000;r=0.587;P=0.000;r=0.634,P=0.000;r=0.654,P=0.000;r=0.649,P=0.000;r=0.655,P=0.001?;small vessel volume in right lung was highly positive correlated with LAA-910 in whole lung and left lung?respectively,r=0.707,P=0.000;r=0.701,P=0.000?,small vessel volume in right lung was moderate positive correlated with LAA-910 in right lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.687,P=0.000;r=0.582,P=0.000;r=0.591,P=0.000;r=0.621,P=0.000;r=0.659,P=0.000;r=0.653,P=0.000?;small vessel volume in left lung was moderate positive correlated with LAA-910 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.667,P=0.000;r=0.667,P=0.000;r=0.629,P=0.000;r=0.538,P=0.000;r=0.619,P=0.000;r=0.628,P=0.000;r=0.579,P=0.000;r=0.596,P=0.004?;small vessel volume in right upper lobe was moderate positive correlated with LAA-910 in right upper lobe?r=0.440,P=0.000?,small vessel volume in right upper lobe was mild positive correlated with LAA-910 in whole lung?right lung?left lung?right lower lobe and left upper lobe?respectively,r=0.350,P=0.005;r=0.369,P=0.003;r=0.314,P=0.013;r=0.253,P=0.048;r=0.356,P=0.004?;small vessel volume in right middle lobe was mild positive correlated with LAA-910 in whole lung?right lung?left lung?right upper lobe?right middle lobe?left upper lobe and left lower lobe?respectively,r=0.327,P=0.010;r=0.322,P=0.011;r=0.320,P=0.011;r=0.267,P=0.043;r=0.258,P=0.000;r=0.339,P=0.007;r=0.261,P=0.041?;small vessel volume in right lower lobe was moderate positive correlated with LAA-910 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.658,P=0.000;r=0.617,P=0.000;r=0.680,P=0.000;r=0.433,P=0.001;r=0.477,P=0.000;r=0.661,P=0.000;r=0.577,P=0.000;r=0.693,P=0.000?;small vessel volume in left upper lobe was moderate positive correlated with LAA-910 in whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.519,P=0.000;r=0.543,P=0.000;r=0.469,P=0.000;r=0.508,P=0.000;r=0.448,P=0.000;r=0.454,P=0.000;r=0.473,P=0.000;r=0.405,P=0.001?;small vessel volume in left lower lobe was moderate positive correlated with LAA-910 in whole lung?right lung?left lung?right middle lobe?right lower lobe?left upper lobe and left lower lobe?respectively,r=0.579,P=0.000;r=0.575,P=0.000;r=0.562,P=0.000;r=0.564,P=0.000;r=0.571,P=0.000;r=0.486,P=0.001;r=0.563,P=0.000?,small vessel volume in left lower lobe was mild positive correlated with LAA-910 in right upper lobe?r=0.399,P=0.001??CONCLUSION:small vessel volume in inspiration and in expiration were positive correlated with LAA-950 and LAA-910,and majority of moderate correlation?In addition,Correlation in expiration is better than in inspiration?Correlation of both of upper lobes is worse than in both of lower lobes?Through this experiment,indirect assessment of emphysema and lung parenchymal destruction can provide effective data support for the clinic?Part?MATERIALS and METHODS:In accordance with inclusion and exclusion criteria 62 COPD Patients were included?Automatic measuring small vessel volume in expiration and in inspiration include whole lung?right lung?left lung?right upper lobe?right middle lobe?right lower lobe?left upper lobe and left lower lobe of COPD Patients based on the platform of FACT-Digital lung^TM?PFT parameters including FEV1?FEV1/Predict?FVC?FEV1/FVC?DLCO?DLCO/Predict?DLCO/VA and DLCO/VA/Predict were measured by spirometer?Both the relationship between small vessel volume in inspiration and PFT and the relationship between small vessel volume in expiration and PFT were used Pearson's correlation analysis?RESULTS:?1?The relationship between small vessel volume in inspiration and PFT:small vessel volume in whole lung was weak negative correlated with FEV1/Predict?FEV1/FVC?DLCO/?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.262,P=0.039;r=-0.272,P=0.032;r=-0.268,P=0.035;r=-0.347,P=0.006?;small vessel volume in right lung was weak negative correlated with FEV1/FVC?DLCO/Predict?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.259,P=0.042;r=-0.255,P=0.046;r=-0.363,P=0.004;r=-0.361,P=0.004?;small vessel volume in left lung was weak negative correlated with FEV1/Predict?FEV1/FVC?DLCO/Predict?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.277,P=0.029;r=-0.266,P=0.037;r=-0.261,P=0.040;r=-0.308,P=0.015;r=-0.300,P=0.018?;small vessel volume in right upper lobe was weak negative correlated with DLCO?DLCO/Predict?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.302,P=0.017;r=-0.303,P=0.017;r=-0.365,P=0.004;r=-0.303,P=0.017?;small vessel volume in left upper lobe was weak negative correlated with DLCO and DLCO/VA?respectively,r=-0.301,P=0.017;r=-0.272,P=0.032???2?The relationship between small vessel volume in expiration and PFT:small vessel volume in whole lung was weak negative correlated with FEV1/Predict?FEV1/FVC?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.427,P=0.001;r=-0.382,P=0.002;r=-0.270,P=0.034;r=-0.253,P=0.047?;small vessel volume in right lung as weak negative correlated with FEV1/Predict?FEV1/FVC and DLCO/VA?respectively,r=-0.397,P=0.001;r=-0.369,P=0.003;r=-0.267,P=0.036?;small vessel volume in left lung was weak negative correlated with FEV1/Predict and FEV1/FVC?respectively,r=-0.417,P=0.001;r=-0.360,P=0.004?;small vessel volume in right lower lobe was weak negative correlated with FEV1/Predict and FEV1/FVC?respectively,r=-0.466,P=0.000;r=-0.367,P=0.003?;small vessel volume in left upper lobe was weak negative correlated with FEV1/Predict?FEV1/FVC?DLCO/VA and DLCO/VA/Predict?respectively,r=-0.284,P=0.025;r=-0.284,P=0.026;r=-0.270,P=0.034;r=-0.253,P=0.050?;small vessel volume in left lower lobe was weak negative correlated with FEV1/Predict and FEV1/FVC?respectively,r=-0.393,P=0.002;r=-0.310,P=0.014??CONCLUSION:small vessel volume in whole lung?right lung?left lung was weak negative correlated with most parameters of PFT in inspiration,and majority of DLCO and related parameters?Correlation between small vessel volume and FEV1 and related parameters in expiration is better than in inspiration?Correlation between small vessel volume and DLCO and related parameters in inspiration is better than in expiration?Correlation between small vessel volume and DLCO and related parameters in both of upper lobes is better than in both of lower lobes?This conclusion will surely provide more reference value for clinical practice?...