The Analysis Of Prognosis Factors For Elderly Patients With Ovarian Cancer

Objective:To investigate the preoperative symptoms of ovarian cancer patients such as abdominal distention,ascites,abdominal pain,vaginal bleeding,abnormality in stool and urine,fatigue,anorexia,personal history as age of menarche,menstruation cycle,menstruation days,menopause age,menopause,number of pregnancies,parity,smoking or not,biochemical indicators such as CA125,platelets,hemoglobin,fibrinogen,related to surgery as clinical stage,pathological type,lymph node metastasis,lymph node dissection,size of residual lesions,these factors in the prognosis of elderly patients with ovarian cancer influences.Method : a retrospective analysis from June 2010 to December 2012 in the First Affiliated Hospital of China Medical University,65 patients received surgery treatment of not less than 50 years of clinical data of patients with ovarian cancer,single factor and multivariate factors data analysis were tested by logistic regression analysis to explore the prognosis of ovarian cancer.Result : Univariate analysis of 24 factors yielded statistically significant(P<0.05)including: bloating,fatigue,platelets,preoperative CA125,clinical staging,and lymph node dissection.Bloating(OR=2.937),fatigue(OR=9.625),clinical stage(OR=2.903)may be risk factors of elderly ovarian cancer.Patients with bloating and fatigue symptoms had worse prognosis than patients without such symptoms.The higher the clinical stage,the older The worse the prognosis of ovarian cancer patients.Lymph node dissection(OR=0.107)may be a protective factor.The prognosis of patients with lymph node dissection was better than that of unswept patients.Although preoperative CA125(OR=1.001)and platelet(OR=1.007)were statistically significant,they were of little clinical significance.No statistically significant factors(P>0.2)included: abdominal pain,abnormalities in two stools,hemoglobin,fibrinogen,menarche age,menstrual cycle,menstrual days,menopause years,smoking,pathological types,lymph node metastasis.Multivariate analysis showed that preoperative CA125(OR=1.001)was statistically significant(P<0.05),but the preoperative CA125 level had little effect on the survival of elderly ovarian cancer.The number of births(OR=2.437)and lymph node dissection (OR=0.073)was associated with prognosis(P<0.05),and it was an independent prognostic factor for elderly ovarian cancer.The parity is a risk factor.The more births,the worse the prognosis of elderly patients with ovarian cancer.Lymph node dissection is a protective factor.Lymph node dissection of elderly ovarian cancer is better than ovarian cancer patients without lymph node dissection.No statistically significant factors included:abdominal distention,fatigue,platelets,menopause,clinical staging,ascites,vaginal bleeding,anorexia,size of residual lesions.Conclusion : Preoperative CA125 levels have no effect on the prognosis of elderly ovarian cancer.The more of the parities,the worse the prognosis.The more radical the lymph node dissection,the better the prognosis.