Prediction Of Prognosis Of Idiopathic Pulmonary Fibrosis By Pulmonary Aorta Artery Diameter Rate

Objective: Idiopathic pulmonary fibrosis(IPF)is one of the most common idiopathic interstitial pneumonia(IIP)and the most commonly diagnosed interstitial lung disease(ILD).The reason is unknown and the prognosis is often not good.Although drugs such as pirenidone have been used to delay progress in recent years,many patients will progress to the late stage of lung function and even require lung transplantation.Therefore,accurately predicting the prognosis of IPF and the referral of early lung transplantation are very important.There are not many predictors of the prognosis of IPF patients.This case study assesses the accuracy of high-resolution computed tomography scan(HRCT)measurements of lung/aortic diameter ratios to assess the survival of patients with IPF.And its clinical application value.Methods: We collected all IPF patient data from the outpatient and ward clinics of the First Affiliated Hospital of China Medical University from 2013 to 2015,and selected the required IPF patient cases through strict exclusion criteria.By selecting the HRCT level of pulmonary artery bifurcation,and measuring the pulmonary artery(PA)and ascending aorta diameter(A)and PA:A ratio,the survival time of patients was followed and the single factor Kaplan-Meier test was used.The prognostic analysis of pulmonary artery size,PA:A and GAP index classification,age,gender,FVC% pred,and DLCO% pred were performed.Then a multi-factor analysis was performed using the Cox proportional hazards model to assess the overall survival of patients with IPF.The impact of the period.Results: Among the 118 IPF confirmed patients included,88 IPF patients with HRCT scans were screened.HRCT measurements showed that the average pulmonary artery diameter and PA:A ratio were 31.84 mm and 0.87,respectively.The univariate Kaplan-Meier test showed that the higher the PA>31.84 mm,PA:A>1,and GAP index grades,the worse the prognosis of IPF patients.There was a statistically significant difference between them(Log Rank test statistic ?2:4.856.7.160;6.909,P<0.05).By analyzing the PA:A and GAP index classification into the multi-factor Cox proportional hazards model,the results showed that PA:A is a risk factor forpredicting the prognosis of patients with IPF,with significant statistical significance(relative risk HR: 4.766,P <0.05),GAP index classification is not meaningful in multivariate analysis.Conclusion: Compared with PA:A?1 IPF patients,PA:A>1,short survival time,poorprognosis,is the main factor affecting the prognosis of IPF,through the detection of lung HRCT can predict the prognosis of the disease.