The Short-term Predicting Value Of Serum Soluble ST2 In Patients With ST-elevation Myocardial Infarction After Primary PCI Treatment

Objectives: study the sST2 level in patients with STEMI after primary PCI treatment and the correlation between sST2 and severity of coronary artery pathological changes,clinical situation,physical examination,biochemical test results and the incidence of MACE for 30 days,to explore the prognostic value of sST2 in such patients.Methods: A total of 128 cases of STEMI after primary PCI treatment were collected from the first hospital of China medical university.Collect patients' clinical information,imageological examination,biochemical test,coronary angiography results.All patients were detected sST2 values by ELISA method and were followed up for 30 days.The results were statistically analyzed.Results:The serum sST2 values of 128 selected patients were examined in this study.The maximum value is 100.72ng/L,and the minimum value is 21.85ng/L,with an average of 46.37ng/L ± 18.33ng/L,and the median is 39.26ng/L.According to the median,dividing all cases into two group: low sST2 value group(A group)and high sST2 value group(B group).There was no difference between 2 groups in age,sex,KILLIP class,EF value,SYNTAX score,peak troponin,Hs-CRP,BNP and creatinine.The odds of hypertension and diabetes in B group is higher than A group.sST2 correlates weakly with EF value(r=-0.204,p=0.021)and Hs-CRP(r=0.256,p=0.004).The odds of heart failure and all MACE in B group is higher than A group.There was no difference between 2 groups in the odds of death,ischemia-driven revascularization and recurrent non-fatal MI.In multivariable analysis,after adjustment for age,sex,hypertension,diabetes,creatinine and KILLIP class,a 1-SD increase in log-transformed sST2 was associated with a 3.419(95%CI:1.893-6.177).In quartile analysis,patients with higher sST2 levels were at increased risk for MACE,with adjusted ORs of 13.613(95%CI: 3.135-59.109)for those in the fourth quartile compared with those below the median.Conclusions: In ST-elevation myocardial infarction after primary PCI treatment,sST2 levels are a independent predictor of MACE.This study highlight the prognosticvalue of sST2 in ST-elevation myocardial infarction after primary PCI treatment.