To Investigate The Value Of Serum C-reactive Protein And Procalcitonin In The Treatment Of Severe Acute Pancreatitis

Objective: Through retrospective analysis,the clinical value of serum C-reactive protein and procalcitonin in the diagnosis and treatment of severe acute pancreatitis was discussed.Methods: One hundred and fifty-one patients with severe acute pancreatitis(SAP)admitted to the First Affiliated Hospital of China Medical University during the period of February 2016 to February 2018 was included in this retrospective study.The treatment methods were selected strictly in accordance with the guidelines and in combination with the patient’s condition and imaging data,and were divided into the drug-conservative treatment group and the surgical intervention group.The clinical features of the two groups of patients were compared.Serum C-reactive protein(CRP)and procalcitonin(PCT)laboratory parameters were observed.Changes in CRP and PCT were recorded for each SAP patient on the day of admission,the first day,and the second day.The situation was divided into elevated group,stable group,and reduced group to observe the proportion of surgical intervention in each group to understand the trend of basic trend of CRP and PCT in surgical intervention patients;and to compare the CRP,the day before admission and the day before surgical intervention in the surgical intervention group.Changes in the PCT.Count data were compared using the χ2 test;measurement data were taken as mean±standard deviation(x ±s),and t-tests were used for comparison of the two-sample mean.Results: There was no significant difference in the age,gender and etiology of the patients in the conservative group and the surgical intervention group(P>0.05);the CRP(119.14±33.25)mg/L,PCT(1.34±0.36)ng/day in the surgical intervention group on the day of admission.The ml was significantly higher than that of the conservative group(107.00±26.8)mg/L,PCT(1.25±0.13)ng/ml,and the difference was statistically significant(P<0.05).The CRP was continuously monitored on the day of admission,the first day,and the second day.The biochemical values of PCT were divided into three groups: elevated group,stable group,and reduced group.Surgical intervention patients accounted for 75% and 84.21% of the elevated CRP and PCT groups,respectively,and 32.14% in the stable group.29.62% in the lower groupaccounted for 3.61% and 2.32% respectively.It was found that the proportion of patients undergoing surgical intervention in the elevated group was higher,while that in the stable group and the lower group was lower;further observation of the conservative group and surgical intervention After three consecutive days of CRP and PCT,the CRP and PCT in the surgical intervention group were significantly higher than those in the conservative treatment group,and there was a tendency for the PCT to continue to rise;the CRP was(261.22±43.24)mg/L 1 day before the surgical intervention.PCT(3.04±1.36)ng/ml was significantly higher than that of surgical intervention group on the day of admission(119.14±33.25)mg/L,PCT(1.34±0.36)ng/ml,the difference was statistically significant(P<0.05).Conclusions: The trend of CRP and PCT biochemical values was monitored.For SAP patients with persistently elevated CRP and PCT,surgical interventions were more likely to occur during this hospitalization period,which would provide some guidance for the early diagnosis and treatment of SAP patients.