Study On The Quality Standard And The Effect Of Warming Kidney And Activating Yang Of Processed Aconitum Carmichaeli

PaoTianXiong is processed into processed goods of root of Aconitum carmichaelii Debx.And it’s one of monkshood processed products.The PaoTianXiong used for health care and food therapy,less used in clinic,but the ancient physicians think especially in syndrome of deficient cold of seminal loss and syndrome of deficiency of kidney essence,and the effect is very good.PTX processing process is complex,and the processing technology of different manufacturers are different,and the production traits of color and characters of gun Tianxiong are large different,and it is not conducive to use and promotion of traditional Chinese medicine.Therefore,it is necessary to improve the quality standard of PTX,and increase its project quality control to ensure safe and effective quality control.At the same time,we try to explore mechanism of action of warming kidney yang of PTX.Lay a foundation for further study on the prospects for promoting PTX.Through access to journal articles,reading books,research at home and abroad,to determine the research status of PTX.Tianxiong name first appeared in the Western Han Dynasty,"Huainan Zi Miao Cheng Xun".This medicine only has its name and not real existence now.A large variety aconite can be processed into TX.Tianxiong processing methods can be traced back to the works of Zhang Zhongjing in the Eastern Han Dynasty "Jingui Yaolue discourse on prescription".TX’s processed methods have gone through many detoxification methods.The current research status of quality standard of PTX and the influence the quality control are understood.Processed methods produce an effect on chemical composition,resistance,pharmacodynamics and toxicity.Determine the kidney yang deficiency model of effective and convenient,and provides a theoretical basis for improving blasting quality standard.PTX’s pre experiment of chemical composition system includes water extract,alcohol extract and petroleum ether extract.The study found that the compounds are most likely to contain the PTX sugar,polysaccharide,glycosides and alkaloids,may contain protein,organic acids,saponins and other ingredients,which lays a foundation for further study of PTX.Study on the quality standard of PTX through machine vision technology,rapid gas phase electronic nose and self observation to describe the characters and improve "Standard of preparation of Chinese herbal medicine in Sichuan"(2015 Edition).By microscopic identification,TLC identification of aconite roots and PTX,it’s qualitative identification.Check and extract include determination of moisture,total ash and acid insoluble ash contents,to increase the gun Tianxiong quality control project.The content of HPLC was used to detect the 13 batch of 3 monoester alkaloids such as benzoylmesaconine,benzoylaconine,benzoyl hypaconitine and 3 diester alkaloids such as mesaconitine,hypaconitine and mesaconitine,to improve the determination limit of PTX.PTX can be roughly divided into three categories,based on cluster analysis,principal component analysis(PCA)and correlation analysis in color and the alkaloid content.That explains the same manufacturers have smaller difference,and different manufacturers have lager difference.At the same time,it’s found color and diester alkaloids total with positive correlation.PTX’s color and alkaloid content can determine whether the excessive processing.With irrigation adenine and resection bilateral adrenalectomy induced kidney yang deficiency,observe the general state,weight,rectal temperature,drinking diet and organ index,serum testosterone(T),cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP)and epinephrine Glucocorticoid(ACTH),thyroid stimulating hormone(TSH),creatinine(Cr),urea nitrogen(BUN),immunoglobulin G(IgG)levels of verification of PTX has the action of Warming Kidney Yang.The PTX has well action of warming kidney yang,and its mechanism may be to improve the hypothalamic pituitary gonadal(HPG)axis and hypothalamic pituitary thyroid(HPT)axis and the hypothalamic pituitary adrenal(HPA)axis and the immune function.In short,this paper improved the quality standard of PTX,verify the action of Warming Kidney Yang of PTX,and investigate its mechanism of action of warming kidney yang.PTX’s safe and effective quality control provides the basic theory,and laid the foundation for the promotion of traditional Chinese medicine in tianxiong.