Clinical Study Of Cold,Heat,Dryness And Dampness Syndrome Elements In Non-small Cell Lung Cancer

Objective:To investigate the distribution characteristics of cold,heat,dryness and dampness syndrome elements in patients with NSCLC,and the correlation between the syndrome elements and age,gender,smoking status,family history,anatomy,pathological type,metastasis,previous treatment and other factors.For the basic theoretical research of lung cancer,as well as TCM syndrome differentiation to provide support and evidence to guide clinical medication.Methods:1.Collect NSCLC cases,extract Chinese medicine diagnosis information and related data(age,gender,smoking status,family history,anatomy,pathological type,metastasis and previous treatment etc.),and input one by one into the Excel table;2.Formulate diagnostic criteria for cold,heat,dryness and dampness syndrome elements,and the elements were used to identify syndromes of cold,heat,dryness,and dampness in each case.3.Statistical analysis of the distribution characteristics of cold,heat,dryness,and dampness syndrome elements in NSCLC,and the relationship between syndrome elements and various research factors.Measured by the mean and standard deviation(x±s),which counts the frequency and composition ratio of the application of statistical description.The relevant data were analyzed using?~2 test and fisher exact probability method(n<40 or T<1).The results were all P?0.05,which was considered as a statistically significant criterion.Results:1.The overall distribution of cold,heat,dryness,and dampness syndrome elements in non-small cell lung cancer patients was dampness>cold>heat>dryness.Single combination of disease,two diseases and three diseases can be seen in clinical practice.The combination of cold+dampness and dampness+heat is the most common.The diagnosis information of the common Chinese medicines in the cold include white coating,tender tongue,swollen tongue and teeth-print,white pelican and aversion to cold;the diagnosis information of the common Chinese medicines in the heat include red or dark red tongue,yellow coating,rapid pulse,fluent pulse,oropharyngeal drying;the diagnosis information of the common Chinese medicines in the dryness include red tongue,slim pulse,constipation,oropharyngeal drying and little coating;the diagnosis information of the common Chinese medicines in the dampness include greasy coating,taut pulse,fluent pulse,swollen tongue and teeth-print,sticky in the mouth ect.2.The cold,heat,dryness and dampness syndrome elements were significantly correlated with the pathological type of non-small cell lung cancer,at the same time,the cold,heat,dryness and dampness syndrome elements were irrelevant with age,gender,smoking status,family history,anatomy,metastasis and previous treatment of non-small cell lung cancer.3.Subgroup analysis of cold,heat,dryness,and dampness syndrome elements and pathological subtypes:at the sex level,there are differences in the distribution of adenocarcinoma and squamous cell carcinoma in different disease factors in male patients,the distribution of cold and dampness in women with adenosquamous carcinoma is not significantly different.At the level of smoking history,adenocarcinoma and squamous cell carcinoma in patients with smoking history were not different in different disease factors.There was significant difference in distribution of adenocarcinoma and squamous cell carcinoma in patients with no history of smoking.At the metastatic level,there was no difference in the distribution of patients with adenocarcinoma and squamous cell carcinoma among different disease factors.There was a significant difference in the distribution of disease factors between adenocarcinoma and squamous cell carcinoma in patients without metastasis.Conclusion:1.The cold,heat,dryness,and dampness syndrome elements of NSCLC patients are mostly dampness,and there are multiple combinations in clinic.The combination of cold+dampness and dampness+heat is the most common.2.The cold,heat,dryness,and dampness symdrome elements are significantly associated with pathological types.Lung adenocarcinomas are mostly cold and dampness.Lung squamous cell carcinomas are mostly heat and dryness.3.In male patients,or in patients with no history of smoking,or in patients without metastasis,adenocarcinomas were more cold and wet,and squamous cell carcinomas were more hot and dry.However,there were no significant differences between female patients,or patients with a history of smoking,or those with metastases.