Clinical Efficacy Of Paroxetine Hydrochloride Tablets In The Treatment Of Functional Abdominal Pain Syndrome

Objective:To research the clinical efficacy of low-dose Paroxetine Hydrochloride in the treatment of functional abdominal pain syndrome through the clinical case study.Methods:From January 2017 to October 2017,67 patients diagnosed as functional abdominal pain syndrome(FAPS)attending the Department of Gastroenterology,Affiliated Hospital of Qingdao University were randomly divided into experimental group and control group,among which 34 patients in the trial group Cases,including 12 males and 22 females,aged 28-75 years,mean age 50.23±12.31 years old;33 patients in the control group,including 11 males and 22 females,aged 25-73 years,mean age About 48.33±13.20 years of age;There was no significant difference in the general conditions of gender and age between the two groups,and they were comparable.Both groups were given Trimebutine Maleate Tablets 0.1g Tid(before meals);Live Combined Bifidobacterium,Lactobacillus and Enterococcus riple Capsules 420 mg Tid(after meals);patients in the trial group were on this basis Paroxetine hydrochloride(Seleprox)was added,and 10 mg Qd(after breakfast)on the first 3 days and 20 mg Qd(after breakfast)after no serious adverse reactions.Followed up for 4 weeks.0,4weeks after treatment,every patient was made scores of Visual Analogue Scale,GAD-7 Anxiety Screening Scale,PHQ-9 Depression Screening Scale.After the treatment,the efficacy was graded according to the following criteria: decrease in the visual analog scale(VAS)of 75% is markedly effective,50%-75% is effective,25%-50% is normal,decrease is ≤25% or the score increases is invalid.Total efficiency =(number of markedly effective cases+ number of effective cases)/ total number of cases × 100%.SPSS 22.0 statistical software was used for statistical analysis of the data obtained from the experiment.Results:Before treatment,there is no significant difference in the visual analog scales(VAS)scores,PHQ-9 depression screening scale,and GAD-7 anxiety screening scale between the two groups(P>0.05).After treatment,the symptoms of abdominal pain and anxiety and depressive were improved in both groups,and the symptoms in the experimental group were more remarkably relieved.The scores of VAS,GAD-7,PHQ-9 were all lower after treatment in both groups(P<0.05).Otherwise,the experimental group were more significant to that of control group.(P<0.05).Compared with the curativeeffect,the number of markedly effective and effective cases in the experimental group is significantly more than the control group.The number of invalid cases in the experimental group was significantly less than the control group.The total effective rate of treatment was significantly higher than that of the control group,and the difference was significant(P<0.05).Conclusions:Low-dose Paroxetine hydrochloride has a significant effect on the improvement of abdominal pain symptoms and mental and psychological disorders in the treatment of functional abdominal pain syndrome patients with anxiety and depression mental disorders.