Clinical Observation Of Chaihu Shugan Powder Combined With Paroxetine Hydrochloride Tablets In The Treatment Of Depression With Liver-Qi Stagnation Syndrome

Objective:To observe the clinical effect and adverse reactions of chaihu shugan powder combined with paroxetine hydrochloride in the treatment of liver qi stagnation syndrome in depressed state.Methods:Using randomized control method,60 patients with mild or moderate depression with liver qi stagnation syndrome who met the inclusion criteria and did not meet the exclusion criteria were divided into treatment group and control group,with 30 cases in each group.The treatment group was treated with chaihu shugan powder combined with paroxetine hydrochloride tablets,while the control group was treated with paroxetine hydrochloride tablets alone.At the same time,the two groups were given some psychological adjuvant therapy on the basis of the drug regimen.The course of treatment was 8 weeks.The Hamilton depression scale(HAMD),depression self-rating scale(SDS),TCM syndrome score,clinical efficacy and TESS score during treatment were observed before and at the 2nd,4th and 8th weeks of treatment for two different treatment schemes,and the treatment effect and adverse reactions of the two groups were evaluated.Results: The comparison between the treatment group and the control group was as follows:(1)There was no statistically significant difference in general information such as gender,age,course of disease and degree of education between the two groups(P>0.05),and general information such as gender,age,degree of education and course of disease between the two groups were comparable.(2)Comparison results of HAMD scores:(1)comparison between groups: comparison of time points showed that HAMD scores of the two groups decreased significantly with the passage of time(P<0.01);The HAMD scores of different groups varied with time(P<0.05).Between the two groups,the HAMD score of the treatment group decreased significantly(P<0.01).(2)Comparison in the group: HAMD scores in both the treatment group and the control group showed a significant decreasing trend with time(P<0.01).(3)Comparison of efficacy: the total effective rate of the treatment group was 82.76%,while the total effective rate of the control group was 78.57%.The difference in HAMD scores between the two groups was statistically significant(P<0.05).According to the results,the HAMD scores of the two groups were compared at week 2,4 and 8 of treatment,and the treatment group had an advantage over the control group.(3)Results of SDS score comparison:(1)Comparison between groups: compared at the time point,SDS score of the two groups showed a significant downward trend with the passage of time(P<0.01);Compared with the group,the decline trend of the two groups was not consistent with time(P>0.05).Between the two groups,the SDS score of the treatment group decreased significantly(P<0.05).(2)Comparison in the group: SDS scores in the treatment group and the control group decreased significantly with time(P<0.01).(3)Comparison of efficacy:the total effective rate of the treatment group was 82.76%,the total effective rate of the control group was 75%,and the difference between the two groups was statistically significant(P<0.05).According to the results,the SDS scores of the two groups were compared at week 2,4 and 8,and the treatment group had an advantage over the control group.(4)Results of TCM syndromes score comparison:(1)Comparison between groups: the comparison of time points showed that both groups showed a significant downward trend with the passage of treatment time(P<0.01);the decrease trend of TCM syndrome score in the two groups was not consistent with time(P>0.05).Between the two groups,the TCM syndrome score of the treatment group decreased significantly(P<0.05).(2)Comparison in the group: the treatment group and the control group decreased significantly with the passage of time(P<0.01).(3)Comparison of efficacy: the total effective rate was 89.66% in the treatment group and 71.43% in the control group,the difference was statistically significant(P<0.05).According to the results,the TCM syndrome scores of the two groups were compared at the 2nd,4th and 8th week of treatment,and the treatment effect of the treatment group was superior to that of the control group.(5)TESS score comparison results: during the 8-week treatment period,nausea and vomiting,diarrhea,insomnia,dizziness,dry mouth and other adverse reactions were compared,and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in appetite loss,headache,tachycardia,sweating and other adverse reactions(P>0.05).Therefore,it can be concluded that TESS score of the two groups of patients,the treatment group has fewer adverse reactions than the control group.In conclusion,according to the comparison results of HAMD,SDS score,TCM syndrome score and TESS score between the treatment group and the control group at week 2,4 and 8,it can be concluded that chaihu shugan powder combined with paroxetine hydrochloride tablets has more favorable therapeutic effect and less adverse reactions.Conclusion(s):Chaihu shugan powder combined with paroxetine hydrochloride tablets in the treatment of depression of liver qi stagnation syndrome has more advantages in clinical efficacy and less adverse reactions.