Analysis Of Sleep Status And Influencing Factors Of Women In Perimenopause And Postmenopause

Objective1.By investigating the sleep status of 412 women aged 40 to 59,we compared and analyzed the sleep status of women in reproductive age,perimenopausal and postmenopausal period,and further explored the factors that affect the sleep status of women in different stages.2.Comparison of sleep status before and after menopausal hormone therapy(MHT)in women with sleep disorders during menopause and postmenopause.Methods1.In this study,412 women aged 40~59 years old were enrolled in the department of gynaecology department of the Second Affiliated Hospital of Chongqing Medical University from September 2016 to September 2017.The study was divided into three groups: reproductive age,perimenopausal and postmenopausal period.The data were obtained by filling out the modified Kupperman Index(KI),the Pittsburgh Sleep Quality Index(PSQI),the Athens Insomnia Scale(AIS),the World Health Organization QOL-BREF Questionnaire(WHO-QOL-BREF)and general situation questionnaire.Multivariate Logisitic regression analysis was used to analyze the influencing factors of sleep disorders.2.MHT in the perimenopausal and postmenopausal women with sleep disorders were evaluated by PSQI and AIS at the end of the 1,3,6 cycle respectively.Results1.In this study,42.5%(175/412)of the women(including insomnia,poor sleep quality or both)had sleep disorders.According to AIS,41.5%(171/412)had insomnia,and according to PSQI,34.5%(142/412)had poor sleep quality.The rate of insomnia increased with age(16.5% to 62.2%,P <0.001).The insomnia rate of perimenopausal and postmenopausal groups(41.1%,65.1%)was significantly higher than that of reproductive age group(11.2%)(P<0.001).The incidence of poor sleep quality increased with the same trend(P <0.001).The scores of PSQI and AIS increased with the development of reproductive age,perimenopause and postmenopausal stages(P<0.05).Vasomotor symptoms(VMS)is positively correlated with sleep disorders(P < 0.001).In women with sleep disorders,KI increased significantly and QOL decreased.2.Multivariate Logistic regression analysis showed that age(?47 years,median),menopausal symptoms and VMS were important influencing factors of sleep disorder(P < 0.05).3.Before treatment and after 1,3,6 cycles of treatment,the AIS average scores were(10.41±2.71),(9.98±2.26),(8.60±1.74)and(7.49±1.48),and the AIS score decreased by about 28.0%.The PSQI average scores were(11.39±3.09),(11.03±2.86),(9.12±2.17)and(7.65±1.56),and the PSQI score decreased by about 32.8%.The scores of “Awakening during the night”(AIS:item 2)and “sleep quality” and “Sleep latency”(PSQI: component 1 and 2)decreased most obviously.Conclusion1.The incidence of sleep disorders increases with age.The sleep status of menopausal and postmenopausal women was worse than that of women of reproductive age.The main symptoms were difficulty in falling asleep,increased frequency of awakening at night,and decreased daytime function,which seriously affect women's quality of life.2.Age,menopause,and menopausal symptoms such as VMS are important factors in the occurrence of sleep disorders.3.MHT can effectively improve the sleep status of most women with sleep disorders during menopause and postmenopause.