Prognosis Of Metabolic Volume Parameters By 18F-FDG PET/CT In Stage ?-? Non-small Cell Lung Cancer

Objective To evaluate the prognostic value of ¹⁸F-FDG PET/CT-basd metabolic tumor volume?MTV?and total lesion glycolysis?TLG?in stage ?-? non-small cell lung cancer?NSCLC?.Methods All of 47 patients with pathological stage on II or III NSCLC who underwent PET/CT before treatment were retrospectively reviewed.Kaplan-Meier method,Log-rank test and Cox proportional hazard model were used to analyze the relationship between metabolic parameters,overall survival?OS?and progression free survival?PFS?.MTV were measured using a cutoff of40%SUV_max.Results The median OS and PFS was 28.93 and 17.37months,and the 1-,2-and 3-year overall survival rate was 80.85%?38/47?,59.57%?28/47?,38.30%?18/47?,respectively.Univariate analysis suggested that SUV_max,M TV and TLG had significant differences on prognostic impact?all P<0.05?.On multivariate analysis,TLG was a risk factor for PFS?HR=5.591,P<0.05?,and MTV was a risk factor for OS?HR=4.369,P<0.05?.MTV was significantly correlated with TNM-staging?r=0.449,P=0.012?.Conclusion MTV is a independent significant prognostic factor for OS in patients with stage II or III NSCLC,and TLG is able to predict the progression of patients with stage II or III NSCLC.