Prognostic Impact Of Volume Metabolic Parameters In PET/CT ¹⁸F-FDG On The Prognosis Of Locally Advanced Cervical Radical Radiotherapy

Background:To compare the prognostic value of different metabolic parameters determined using ¹⁸F-FDG PET/CT with other clinical and pathological prognostic parameters in locally advanced cervical radical radiotherapy?LACC?.Methods:fifty-two patients with LACC underwent pre-therapy¹⁸F-FDG PET/CT parameters including maximum and mean tumor standardized uptake values?SUVmax,SUVmean?,metabolic tumor volume?MTV?and tumor glycolytic volume?TGV?were measured before the start of CRT.These parameters were compared to other clinical prognostic factors.Survival curves were estimated by using the Kaplan-Meier method.Cox regression analysis was performed to determine the independent contribution of each prognostic factor.Results:After 39.95 months of median follow-up?range,11.29⁶6.00?,In univariate analysis,International Federation of Gynecology and Obstetrics stage??2=9.13,P=0.028;?2=9.07,P=0.028?,TGV??2=8.01,P=0.005;?2=7.19,P=0.070?were significant predictors of progression-free survival?PFS?and overall survival?OS?.multivariate analysis,Only TGV negatively influenced OS and PFS?RR=1.403,P=0.006;RR=1.398,P=0.006?were independent prognostic factors for predicting PFS and OS.Conclusions:TGV,a volume-based metabolic paramete may be significant independent prognostic factors for PFS and OS.