Effects Of Nicorandil On Vascular Function And Inflammatory Factors After Percutaneous Coronary Intervention In Elderly Patients With Coronary Heart Disease

Background: With percutaneous coronary intervention and antiplatelet aggregation drugs are widely used,PCI surgery has become elderly acute coronary syndrome,acute coronary syndrome,ACS)in patients with blood circulation reconstruction of the important means,but also because of intraoperatie postoperative thrombosis fall off cause vascular occlusion distal vascular embolization or edge,cause a variety of severe myocardial ischemia anoxic injury.Objective: To investigate the effects of nicorandil on vascular endothelial function and c reactive protein(CRP)level after PCI in elderly patients with ACS.Methods: Ninety elderly patients with ACS were randomly divided into nicorandil group and control group.The changes of endothelin(et)-1,nitric oxide(no)and CRP were detected at 1 day before operation,1 day after operation and 1 month after operation.Results: There was no significant difference between the two groups before treatment(P>0.05).Compared with 1 day before treatment,the level of no decreased and the level of CRP increased on the 1st day after operation in the two groups.1 month after operation,the level of no increased and the levels of ET-1 and CRP decreased(P<0.05).The level of no in the group of nicordil was significantly higher than that in the control group.The levels of ET-l and CRP in the control group were significantly lower than those in the control group(P<0.05).Conclusion: On the basis of routine optimization of anti-myocardial ischemia therapy after PCI in elderly patients with ACS,continuous administration of nicorandil for 1 month could significantly improve vascularendothelial function and slow down vascular inflammation.