Clinical Study Of Single Layer Artificial Dermis Combine With Autologous Split-thickness Skin Repairing Diabetic Foot Wound Graded As Wagner Level 3

Objective:Through the clinical trials,to observe the therapy effects of single layer artificial dermis combine with autologous split-thickness skin in repairing diabetic foot wound graded as Wagner Level 3.Make a comprehensive evaluation of single layer artificial dermis combine with autologous split-thickness skin repairing diabetic foot,to provide a reference for the new clinical treatment of diabetic foot wound.Methods:Group design was applied in this experiment,according to include and exclude standards,observe the collection of 37 patients with single artificial dermis with split-thickness skin graft to repair the wound patients clinical data of 37 cases with simple autologous split-thickness skin graft to repair the wound patients clinical data.Using the random number table from 37 patients with single artificial dermis with autologous split-thickness skin graft to repair wounds of patients.24 patients were randomly selected as test group from 37 patients with single artificial dermis with split-thickness skin graft,and 24 patients were randomly selected as control group from 37patients with simple autologous split-thickness skin graft to repair wounds.Respectively to observe wound healing rate in day 7 and day 14,wound healing time,appearance shape after wound healing,Bacteriology inspection,hospitalization expenses and hospitalization days,etc.This experiment adopted SPSS21.0 statistical analysis software for analysis the collected data.Count data using%describe,comparison between the groups using Chi-Square test.Normal distribution of measurement date using Mean±Standard deviation????±s?to describe,comparison between the groups using t test.Non-normal distribution of measurement date using Median?std.Deviation?[M(P₂₅,P₇₅)]to describe,comparison between the groups using Wilcoxon rank test.Correlation analysis using the spearman rank correlation test.?=0.05,P<0.05 for the difference is statistically significant.Results:1.Wound healing rate:The wound healing rate after seven days:experimental group for?0.87±0.05?,control group for?0.81±0.07?,experimental group was higher than control group,?t=-3.02,P<0.01?,the difference was statistically significant.After fourteen days,wound healing rate also experimental group was higher than control group,the difference was statistically significant??²=-4.17,P<0.01?.2.The wound healing times:Experimental group was for?22.13±3.59?days,control group was for?28.17±6.24?days,experimental group was lower than control group,the difference was statistically significant?t=1.47,P<0.01?.3.Follow-up after wound healing,skin of the wound in the experimental group was more smooth and good elasticity,ulcer recurrence possibility as smaller,and light scar hyperplasia.Healing effect in experimental group was better than control group.4.Bacteriology inspection:Five days after artificial dermis transplantation,bacteriology infection rate was 25%,the rate of control group was 37.5%,there was no significantly difference in the two group?P=0.57?.5.Hospitalization expenses:experimental group was for 3.41?0.32?,control group was for 3.10?0.30?,the former was higher than the later,the difference was statistically significant?Z=-3.71,P<0.01?.6.Hospitalization days:experimental group was for 31?9?,control group was for 32.50?13?,there was no significantly difference in the two group?P=0.21?.Conclusion:Single layer artificial dermis combine with split-thickness skin grafts to repair diabetic foot chronic wound may increased operations,and compare with control group,there was no significant differences in hospitalization days,and hospitalization expenses.Artificial dermis combine with split-thickness skin grafts has better clinical application.