| Objective: To investigate the serum IL-17 level and its clinical significance in patients with different urinary albumin excretion rate in type 2 diabetes mellitus.Method:A total of 160 inpatients in the First Affiliated Hospital of China Medical University from January 2017 to December 2017 were collected and used for screening and diagnosis of microalbuminuria according to ADA(2012)recommended by the United States Urinary Albumin Excretion Rate(UACR,urinary albumin/urinary creatinine)were divided into normal albuminuria group(T1 group),early diabetic kidney disease group(T2 group)and clinical diabetic kidney disease group(T3group).60 normal cases served as control group(T0 group).Record all the research object of age,gender,height,weight and their body mass index,collect early morning urine and venous blood,urine albumin was detected,urine creatinine,FPG,Hb A1 C were calculated,using enzyme linked immunosorbent assay to detect the concentration of serum IL-17.Results: Compared with T0 group,serum IL-17 in T2 DM patients increased significantly and increased with the increase of urinary albumin excretion rate,and the difference was statistically significant(P<0.05).SCr,BUN and blood il-17 were all major factors influencing Ln(UACR).Serum il-17 was positively correlated with FBG,HbA1 C,SCr,BUN,and Ln(UACR)(P <0.01).Conclusion: Serum IL-17 more early than UACR showed a trend of increase,and increased with the progression of diabetic nephropathy,Serum IL-17 may become the new early diagnosis of diabetic nephropathy and an important index for judging progression.Serum IL-17 may be more sensitive to early diagnosis of diabetic nephropathy than UACR. |
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