The Preventive Effect Of Early Use Of Pulmonary Surfactant On Neonatal Respiratory Distress Syndrome

Objectives To investigate the effect of early application of pulmonary surfactant on the prevention and treatment of neonatal respiratory distress syndrome;To guide the clinical treatment of premature infants with different gestational age,so as to achieve the best therapeutic effect.Methods According to the criteria for inclusion and exclusion,A total of 135 premature infants who were born birth from January 2016 to December 2017,Gestational age between 27⁺¹³2⁺⁶weeks admitted to NICU of Tangshan Maternity and child health care hospital were collected.According to whether the parents agreed to apply pulmonary surfactant at the early stage,the children who met the requirements were divided into two groups:early PS application group?PS group?and early nCPAP application group?nCPAP group?.According to gestational age,they were divided into small fetal age group?group PS₁ and group nCPAP₁?and large gestational age group?including PS₂group and nCPAP₂ group?.The clinical data of mothers' pregnancy,postnatal condition and the situation in NICU were collected through the records of the child's mother's previous cases and the records of the patient's disease log,Including the medical history of mother's pregnancy,the use of effective hormones before birth,the way of childbirth in preterm infants,the occurrence of NRDS,the use of PS,the time of hospitalization and oxygen consumptionthe,the total hospitalization expenses,complications during the treatment and the occurrence of death,etc.Through statistical analysis,whether there is significant difference in the above indicators,and compare whether there are differences in these indicators between the two groups of children in different gestational age,so as to further clarify the clinical value of early application of PS to prevent and treat of NRDS.Results 1 There were no statistically significant differences in General condition of mother's pregnancy and after birth between PS group and nCPAP group.?P>0.05?.2There were no statistically significant differences in the incidence of NRDS,the fatality rate,the usage rate of ventilators,all time of Oxygen inhalation,the usage rate of second dose PS,hospital day and complication between PS group and nCPAP group?P>0.05?.3The PS usage and total hospitalization expenses of the PS group were Significantly higher than those in nCPAP group,and the differences were statistically significant?P<0.05?.4There were no statistically significant differences in General condition of mother's pregnancy and after birth between PS₁ group and nCPAP₁ group.5 There were no statistically significant differences in the usage rate of second dose PS,all time of Oxygen inhalation,hospital day and complication between two groups in the range of small gestational age.6 In the range of small gestational age,The PS usage and total hospitalization expenses of the PS₁ group were Significantly higherthan those of nCPAP1 group;But the incidence of NRDS and the fatality rate of the PS1 group were Significantly lower than those of nCPAP₁ group,and all the differences were statistically significant?P<0.05?.7 There were no statistically significant differences in General condition of mother's pregnancy and after birth between PS2 group and nCPAP2 group.8There were no statistically significant differences in the incidence of NRDS,the usage rate of second dose PS,the usage rate of ventilators,all time of Oxygen inhalation,hospital day,complication and he fatality rate between two groups in the range of large gestational age?P>0.05?.9 In the range of large gestational age,The PS usage and total hospitalization expenses of the PS₂ group were Significantly higher than those of nCPAP₂group?P<0.05?.Conclusions 1 Early application of pulmonary surfactant to prevent the occurrence of NRDS does not apply to all preterm infants.It has different effects on preterm infants of different gestational age.2 Early application of pulmonary surfactant has a certain effect on prevention and treatment of NRDS in premature infants with gestational age of27⁺¹²9⁺⁶,and has not increased other complications.3 Early application of pulmonary surfactant has no effect on the prevention and treatment of NRDS in premature infants with gestational age between 30⁺⁰³2⁺⁶.