| Objectives Chronic hepatitis B,hepatitis B cirrhosis and primary liver cancer are all stages of chronic HBV infection.Objective to explore the differences of hepatitis B virus markers and DNA levels in different stages.Analysis of the relationship between HBV content and the progression of disease.It provides a reference for the early diagnosis,timely treatment,delay of the progress of the disease and the improvement of the prognosis of the different stages of chronic HBV infection.Methods This was a retrospective study.636 cases of patients with chronic HBV infection who met the requirements of hepatitis B virus markers and DNA were enrolled in the hospital were collected from January 2015 to August 2016 in Tangshan Infectious Disease Hospital,including 222 cases of chronic hepatitis B,256 cases of hepatitis B liver cirrhosis and 158 cases of primary liver cancer.Analysis of the difference of HBV markers(HBsAg,HBs Ab,HBeAg,HbeAb)and HBV DNA in three groups of patients with chronic hepatitis B,hepatitis B cirrhosis and primary liver cancer.At the same time,grouped according to the patient's with complications(upper gastrointestinal bleeding,spontaneous bacterial peritonitis,hepatic encephalopathy,cholelithiasis)or not and ChildPugh grading standard in patients with hepatitis B cirrhosis.There were 84 cases with complications,172 cases without complications;133 cases of Child A class,69 cases of Child B class and 54 cases of Child C class.The changes of HBV markers and HBV DNA content between groups with or without complications and different Child-Pugh classification groups were observed and the clinical significance was analyzed.Results 1 There was no significant difference in sex composition between the three groups of chronic hepatitis B,hepatitis B cirrhosis and primary liver cancer(P>0.05).The average age of the three groups was(45.92±14.78),(52.43±10.26),and(56.04±12.06)years old,respectively.The age difference between the three groups was statistically significant(P<0.01).Among the young people(age?44 years old),the content of HBsAg,HBeAg,HBeAb and HBV DNA in the three groups were compared,the difference was statistically significant(P<0.05).After comparison with each other,the levels of HBsAg,HBeAg and HBV DNA in hepatitis group were all higher than those in liver cirrhosis group and liver cancer group.The content of HBeAb was lower than that in the liver cirrhosis group and liver cancer group.The difference was statistically significant(P<0.05).There was no statistically significant in liver cirrhosis group and liver cancer group(P>0.05).There was no statistical difference between the three groups of patients with HBsAb(P>0.05).Among the middle aged(45~59 years old),the content of HBsAg,HBeAg,and HBV DNA in the three groups were compared,the difference was statistically significant(P<0.05).After comparison with each other,the levels of HBsAg,HBeAg,and HBV DNA in hepatitis group were all higher than those in liver cirrhosis group and liver cancer group.The difference was statistically significant(P<0.05).There was no statistically difference between the liver cirrhosis group and the liver cancer group(P>0.05).There was no statistical difference between the three groups of patients with HBsAb and HBeAb(P>0.05).Among the elderly aged(age?60 years old),the three groups of patients with HBsAg?HBsAb?HBeAg?HBeAb?HBV DNA comparison,the difference was not statistically significant(P>0.05).2 There was no significant difference in age and sex composition between the two groups of patients with hepatitis B cirrhosis with complications and no complications(P>0.05).The contents of HBsAg,HBeAg and HBV DNA in patients with complications were lower than those without complications.The difference was statistically significant(P<0.05).There is no significant difference in the content of HBsAb and HBeAb in the two groups(P>0.05).3 There is no significant difference in sex composition and age between the three groups of Child A,B and C class(P>0.05).The difference of HBsAg and HBV DNA between the three groups was statistically significant(P<0.05).And the content of HBsAg and HBV DNA was the lowest in Child A class,the highest in Child C grade.There was no significant difference in the other indicators between the three groups(P>0.05).Conclusions 1 Among the young and middle-aged patients,with the progression of chronic hepatitis B to liver cirrhosis and liver cancer,the levels of HBsAg,HBeAg and HBV DNA will decline gradually.2 The level of HBsAg and HBV DNA is lower in cirrhotic patients with complications than in patients without complications.3 The higher the Child-Pugh level,the higher the content of HBsAg and HBV DNA. |
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