The Relationship Between Cumulative Systolic Blood Pressure Exposure And Cognitive Function In Middle-Aged And Elderly People Of Kailuan Group

Objectives Among the middle-aged and elderly adults,to explore the association between cumulative SBP exposure and cognitive function.Methods From 2006 to 2007,employees in kailuan group had their first physical examination.After that,these people went on a physical examination every two years.In 2012-2013,they had done the fourth physical examination,and finished the measurement of cognitive function(MMSE score).Deleted the people who is absent with blood pressure or MMSE score,2211 participants with integrated data were included to the study.The the cumulative SBP was calculated by consecutive SBP values measured through 2006–2007 ? 2008-2009 ? 2010-2011 ? 2012-2013.In order to analyze the relationship between cumSBP and MMSE score,the multivariate logistic regression analysis was applied.Results The average age of 2211 participants was 51.04±10.56,the number of male was 1295 and the female was 916.The people who were diagnosed with cognitive impairment were 167(7.5%).Logistic regression analyses showed that the risk of cognitive impairment was significantly increased in participants with cumSBP ?868mmHg(OR: 2.25;95% CI: 1.21~4.18;P=0.009).Conclusions Higher cumulative SBP was the risk factor for worse cognitive performance.Compare to baseline high blood pressure,the association between cumula tive SBP and cognitive function decline was stronger.