Clinical Observation On Treatment Of Cervical Human Papillomavirus Infection With Heyixiao And Ganoderma Lucidum Dispersible Tablets

Objective: on the basis of previous studies,the purpose of this study was to treat high risk human papillomavirus infected cervical by external application of Heyixiao granules and Ganoderma lucidum dispersible tablets,and to observe the clinical efficacy of the combined therapy.In order to shorten the course of high-risk HPV infection,and to explor an optimized treatment scheme for cervical high-risk HPV infection.The relationship between high-risk cervical HPV infection and immune and the mechanism of Heyixiao granule in the treatment of the disease were discussed.Methods: 91 subjects were randomly divided into trial group(n = 32),control group1(n = 29)and control group 2(n = 30).Three menstrual cycles and Ganoderma lucidum dispersible tablets(3 tablets per day,3 times a day,10 days a course of treatment,3 courses of treatment),control group 1 single use of Heyiexiao granule,control group 2 group single use of Ganoderma lucidum dispersible tablets,The course of treatment was the same as that in the treatment group.Reexamination after withdrawal of the drug,the improvement of TCM symptoms before and after treatment in the three groups was counted.The rate of HPV turning negative,cervical liquid-based cytology,TCT,disease examination etc.Cervical histopathological examination and changes of regulatory T cells were used to compare the clinical efficacy of three regimens in the treatment of high risk HPV infection of cervix.Results:The negative conversion rate of HR-HPV was 81.25 in the trial group,68.97 in the control group and 26.67 in the control group,the difference among the three groups was statistically significant(P<0.01).The differences among the groups were statistically significant(P<0.05.The total effective rate of TCM symptom improvement was 90.63 in the experimental group,62.07 in the control group and 26.67 g in the control group,and the difference was statistically significant(P<0.01).The differences among the groups were statistically significant(P<0.05).There was no significant difference in TCT between the three groups before and after treatment(P>0.05),but there was significant differencebetween the three groups after treatment(P<0.01).The difference between the two groups was statistically significant(P<0.01).There was no significant difference between control group 1 and control group 2(P>0.05).There was no significant difference in the results of cervical examination before and after treatment in the three groups(P>0.05),and there was statistical difference between the three groups after treatment(P<0.05).There were significant differences between test group and control group 2,control group 1 and control group 2(P<0.05).There was no significant difference between the trial group and the control group(P>0.05).The changes of regulatory T cells in the three groups were compared before and after treatment,and the differences in the 2 groups were statistically significant(P<0.05),but there was no significant difference in control group 1(P>0.05).Conclusion: Heyixiao granules combined with Ganoderma dispersible tablets can effectively improve the symptoms of patients with cervical HR-HPV infection,such as subclinical abnormalities,sexual bleeding,pruritus of pudenda,drowsiness or fatigue,and can significantly improve the negative rate of HR-HPV,and can regulate body immunity.Combination therapy or single use of Heye Yixiao granule can effectively improve the results of TCT and biopsy in patients.In general,the efficacy of combined therapy in treating high-risk HPV infection of cervix is better than that of single drug.Can reduce the patient's cervical disease further development probability.