| Objective:To develop the Parental EV71 vaccine hesitancy survey questionary,and estimate feasibility of the survey questionary.To survey proportion and influencing factors of EV71 vaccine hesitancy among children parents,providing evidence for making intervention strategies and activities to addressing EV71 vaccine hesitancy.Methods:On the basis of literature reviewing,using the standards of importance score means and variation coefficient to select the indicators and questions by Delphi method.Used average survey time and completeness to estimate feasibility.Selected parents of 6-18 month children for a questionnaire-based survey from 12 healthcare clinics in 4 cities of Sichuan,Yunnan province by convenience sampling.The influencing factors of hesitancy were evaluated by univariate and multivariate analysis.Results:1.The average age of experts who joined two rounds of consultation was 48.271±5.83 years and the mean working years in their own areas was 19.58±2.43.65%of them were professor rank and 85%major in immunization program.The first round response rate was 88.0%,experts authority was 0.86,and Kendall W coefficient was 0.391,?2=135.95,df=87,P<0.001.The second round response rate was 90.9%,experts authority was 0.89,and Kendall W coefficient was 0.410,?2=150.46,df=66,P<0.001.After twice consultation,there were 48 questions,including six aspects of general socio-demographic characteristics,HFMD cognition,EV71 vaccine cognition,vaccination attitudes,vaccination behaviors,and vaccine hesitancy classification.In pre-survey,average survey time was 8.7±2.1 min,completion rate was 90.0%(27/30).Average ssurvey time in field survey was 8.5 ± 1.9 min,completention rate was 88.6%(328/370).2.210(64%)parents knew basic information of HFMD,while 122(37.2%)knew EV71 vaccine basic information,?2=41.40,df=1,P?0.001.As for HFMD,awareness rate of HFMD symptoms was the highest(91.5%),while awareness about severe HFMD and EV71 virus was lowest(40.9%).As for EV71 vaccine,awareness about early vaccination was the highest(54.6%),and awareness about inoculation time was the lowest(21.6%).3 33.8%(111/328)parents were vaccine hesitancy,while 6.7%(22/328)parents completely refused EV71 vaccine.The price of EV71 vaccine(expensive vs acceptable,OR=3.04,95%CI:1.26-7.33;don't know vs acceptable,OR=3.03,95%CI:1.29-7.15),concern of severe adverse effect after EV71 vaccination(OR=2.47,95%CI:1.04-5.88),experience of rejecting vaccine(OR = 2.76,95%CI:1.07-7.15)and unsatisfactory vaccination experience(OR = 2.21,95%CI:1.16-4.20)were risk factors for vaccine hesitancy.While Children are older(13-18 month vs 6-12 month,OR=0.32,95%CI:0.11-0.90),recommendation from health professionals(OR=0.31,95%CI:0.15-0.64),knowing basic information of EV71 vaccine(OR=0.38,95%CI:0.17-0.84),the higher risk for HFMD(OR=0.39,95%CI:0.19-0.80),severity of HFMD(OR=0.38,95%CI:0.17-0.85),trusting effectiveness of EV71 vaccine(OR=0.27,95%CI:0.14-0.51)were protective factors.Conclusion:(1)Parental EV71 vaccine hesitancy survey questionary was a feasible and appropriate cross-sectional survey questionary for EV71 vaccine hesitancy in China wetstern population.(2)While 1/3 parents were EV71 vaccine hesitancy,only few parents completely refuse EV71 vaccine in Sichuan,Yunnan province.The proportion of EV71 vaccine hesitancy in those regions was high.(3)Lacking of knowledge about EV71,perceived low risk of HFMD,concerns about safety and effectiveness of EV71 vaccine,feeling vaccine was expensive,children was young,unsatisfactory vaccination experiences can lead to EV71 vaccine hesitancy. |
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