The Evaluation Of The Tremor And Motor Delay In The Upper Limbs Of Parkinson's Patients

Objective:Using the smart phone measure the tremor and bradykinesia on the upper limb of the Parkinson's patients and comparing with the traditional scoring scale,Try to explore the connection between them.Methods:We recorded the information such as lateralization,H-Y scale,drug usage,age and gender of 64 Parkinson's patients,used smart phone and specified application to record and calculate the speed and frequency of the alternate motion and tremor on upper limbs,at the same time,we need to complete the UPDRS-?,and divide all of patients into 2 groups named early stage(H-Y= 1-2.5)and the middle-late period(H-Y= 3-5)according to the H-Y scale.Then we need to use the independent-samples T test and Kruskal-Wallis compare the differences among groups of indicators for smart phone evaluation,we also have to use the paired-samples T test compare the patient's data before and after medication as to compare the differences between groups of indicators by using smartphone and UPDRS-?.Finally,we need to analyze the various indicators of smartphone and UPDRS-? with bivariate correlation.All of the statistical result demonstrated in forms and graphs.Results:1.Compared with the bilateral rotation speed,rotation frequency and tremor strength,rotation frequency of sick side(P=0.00)and lighter side(P=0.05)measured by smartphone have more significant differences in the early and middle-advanced stages of PD.2.Compared with the bilateral tremor strength(P>0.05)measured by smartphone,UPDRS-?(P=0.002)have more significant differences in the early and middle-advanced stages of PD.3.Compared with the rotation frequency,vibration frequency of sick side and rotation speed,rotation frequency,and vibration frequency of lighter side(P>0.05),rotation speed of sick side(P=0.02)measured by smartphone have more significant differences before and after taking medicine.4.UPDRS-?,tremor strength of sick side and lighter side(P>0.05)measured by smartphone have no significant differences before and after taking medicine.5.Compared with the dominant side,diadochocinesia of the nondominant side(r=-0.428?-0.304)measured by smartphone have more significant correlation with UPDRS-?.6.Compared with the nondominant side,tremor of the dominant side(r=-0.202?0.348)measured by smartphone have more significant correlation with UPDRS-??7.Compared with tremor,diadochocinesia of the dominant side(r=-0.390?0.348)measured by smartphone have more significant correlation with UPDRS-?.8.Compared with tremor,diadochocinesia of the nondominant side(r=-0.428?-0.304)measured by smartphone have more significant correlation with UPDRS-?.9.Compared with lighter side,rotation speed,tremor strength of sick side(r=0.379)measured by smartphone have more significant correlation with UPDRS-?.10.Compared with tremor strength(r=0.379),rotation speed of sick side(r=-0.466)have more significant correlation with UPDRS-?;however,Compared with rotation speed(r=-0.304),tremor strength of lighter side(r=0.367)have more significant correlation with UPDRS-?.11.The tremor strength of the tremor-type and nontrenor-type patients measured by smartphone have no significant correlation with UPDRS-?.maybe it is unsuited to measure tremor by smartphone on Parkinson's patients.Conclusion:It is helpful to measure the static tremor and diadochocinesia for Parkinson's patients by uaing smartphone,the assessment result may reflect the disease severity.Compared with UPDRS-?,diadochocinesia measured by smartphone was preferable to static tremor.Diadochocinesia of the nondominant side was superior to the dominant side,sick side was superior to lighter side;static tremor of the nondominant side was superior to the dominant side,the lighter side was superior to the sick side.