Study On The Association Between Uric Acid And Insulin-like Growth Factor-1 In Children With Idiopathic Short Stature

Objective: The aim of this study was to examine the relationship between serum uric acid(UA)levels and insulin-like growth factor-1(IGF-1)in children and adolescents with idiopathic short stature(ISS).Methods: A total of 91 children who were hospitalized and diagnosed as ISS in Affiliated Hospital of Jining Medical University from January 1,2015 to December 31,2016 were enrolled in the study.The basic data collected including name,gender,age,pregnancy history and production history,birth history,growth history and family history;physical examination data including height,weight,growth velocity,blood pressure includes systolic blood pressure and diastolic blood pressure,development status,calculated the height percentile and body mass index;laboratory examination including blood routine,fasting plasma glucose,liver function,kidney function,thyroid function,gonadal six items,adrenocorticotropic hormone and cortisol rhythm(0,8 and 16 o'clock),peak value of growth hormone stimulation test,IGF-1,calculate the standard deviation of IGF-1(IGF-1 SDS);Imaging examination items including left hand and wrist joint radiographs,abdominal ultrasound,gynecological ultrasound and magnetic resonance imaging(MRI),etc..Results: The mean age of the subjects was(10.1±3.8)years.The levels of IGF-1 SDS and UA were(-0.65±1.19)ng/ml and(271.39±70.28)?mol/L,respectively.A univariate analysis displayed a significant positive correlation between the IGF-1 SDS and age,height,body weight,body mass index,creatinine,UA and puberty stage(P<0.05),whereas a significant negative correlation was found between the IGF-1 SDS and low-density lipoprotein cholesterol and aspartate transaminase(P<0.05).In multivariate piecewise linear regression,the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168?mol/L and 301?mol/L(?=0.010,95%CI:0.004-0.017,P=0.002).The levels of IGF-1 SDS decreased with the elevation of UA when UA was less than 168 ?mol/L(?=-0.055,95%CI:-0.081--0.028,P<0.001)or more than 301?mol/L(?=-0.005,95%CI:-0.013-0.002,P=0.174).Conclusions: The study demonstrated a nonlinear relationship between UA levels and IGF-1 in children and adolescents with ISS.This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1.