Establishment The Model Of Depression After Stroke And Observation The Behavior After Fluoxetine Treatment

Objective:Establishment the model of depression after stroke.Assess the behavior of depression rats in each group and Observe the effect of fluoxetine on depressive behavior and neurological function in rats.Methods:Middle cerebral artery occlusionwas used to establish the model of focal cerebral ischemia.Chronic unpredictable mild stress was combined with isolation to establish post-stroke depression.Through a series of behavioral tests,including forced swimming test,open box test and sucrose preference test,the depressive behavior of rats in each group was tested.Observed the effect of fluoxetine on body weight,depressive behavior and neurological deficit in rats.Results:1.A rat model of post-stroke depression was successfully prepared using middle cerebral artery occlusion combinedwith chronic unpredictable mild stimulation and isolation.2.In body weight,compared with the control group and the stroke group,the body weight of the PSD group gradually decreased(P <0.05);Compared with rats in PSD group,the body weight of FLU rats gradually increased(P<0.05);3.In the sucrose preference test,compared with the control group and the stroke group,the proportion of sucrose water consumption in the PSD group gradually decreased(P<0.05);(P<0.05).Compared with the PSD group,the proportion of sucrose water consumption in the FLU group gradually increased(P<0.05);4.In the open-fieldtest,compared with the control group and the stroke group,the scores of movements in the PSD group gradually decreased(P<0.05);Compared with the PSD group,thescores of the movements of the FLU group gradually increased(P<0.05);5.In the forced swimtest,compared with the control group and the stroke group,the immobility time of the rats in the PSD group was significantly increased(P<0.01).Compared with the PSD group,the immobility time of the rats in the FLU group was reduced(P<0.01);6.In the modified Neurological Severity Scores,compared with the control group and the stroke group,the PSD group rats had higher scores(P<0.01).The FLU group scores were lower than the PSD group(P<0.05)Conclusion:1.A rat model of post-stroke depression was successfully prepared using middle cerebral artery occlusion combinedwith chronic unpredictable mild stimulation and isolation.2.Fluoxetine is effective in treating post-stroke depression and has a positive effect on ischemic stroke neurological deficits.