The Diagnostic Value Of DTI And DKI Technique In Degeneration Of Corpus Callosum Of Chronic Alcoholism

Chronic alcoholism is a common disease on a global scale.It affects human health in different degrees.The disease was first publicly reported in 1903 by Italy’s pathophysiologists Marchiafava and Bignami.The disease is common in patients with chronic alcoholism,due to long-term heavy drinking and related diseases caused by varying degrees of damage to the nervous system.Clinical manifestations include dizziness,involuntary tremors in hands and feet,headache,memory loss or loss.Severe conditions can lead to confusion and even death.The etiology and pathogenesis of MBD have not yet been clearly established.Most scholars believe that MBD is the result of a common interaction between chronic alcoholism and varying degrees of malnutrition.MBD currently relies mainly on patient-related medical history,clinical symptoms,and related imaging studies for clinical diagnosis.Among them,imaging examination methods mainly include CT and MRI imaging.CT can detect changes in carotid body shape and density in patients with advanced MBD.MRI can prompt the disease earlier and more sensitive than CT,especially in recent years,the development and application of MRI functional imaging software has a clear advantage for the earlier and accurate diagnosis of the disease.In China,with the continuous improvement of people’s quality of life,the incidence of MBD presents a rapid upward trend.Ordinary traditional examination methods are difficult to diagnose chronic alcoholism and caries degeneration.In our daily work,we can see that the mild early degeneration of the body’s normal CT and MRI often showed negative,but clinical symptoms such as memory loss,hand,foot and tremor,nystagmus,unstable walking and other clinical symptoms,these clinical The performance does not match the results of the imaging examination.In order to make up for the insufficiency of the above aspects,this study uses DTI and DKI techniques comprehensively,and uses the actual measured values(FA,ADC,and MK values)measured by this technique to analyze the objective data of the carcass microscopic changes,and to explore the use of nuclear magnetic imaging.Diagnostic Value of FA,ADC and MK Values in the Degeneration of Chronic Alcoholism.To evaluate the diagnostic value of diffusion tensor imaging(DTI)and diffusion kurtosis imaging(DKI)in the diagnosis of Chronic Alcoholism with Corpus Callus(MBD)and analyze it using ROC curves.The diagnostic value of each relevant parameter for this disease provides an objective reference for clinical diagnosis and treatment of the disease.Sixty-eight patients with chronic alcoholism who were treated in our hospital from July 2015 to February 2017 were collected.Sixty normal middle-aged people were used as a control group.Routine MRI examination revealed changes in brain parenchymal morphology and signals caused by chronic alcoholism.Using the commonly used parameters(FA,ADC,MK)in DTI and DKI techniques to measure the knees,body,and compression of the carcass,the ROC curves of each parameter in the diagnosis of chronic alcoholism were drawn,and the parameters were determined.Critical values,analyze and evaluate the clinical significance of FA,ADC,and MK values in the diagnosis of this disease.Results There were 51 cases with brain atrophy in different degrees.The imaging findings showed a decrease in the size of the brain gyrus,a widening of the sulcus of the brain in the corresponding site,and a different degree of expansion of the ventricular system.The largest number of cerebellar hemispheres with brain atrophy was 39 cases.The main site of cerebellar hemisphere atrophy was located in the cerebellar vermis.The main areas of brain atrophy were cerebral cortical gray matter,simple brain atrophy in 3 cases,and simple cerebellar atrophy in 2 cases.White matter demyelination in 13 cases,the conventional MRI showed multiple patches of long T1 long T2 signal around the lateral ventricle,high-pressure water image showed a signal,the boundary is blurred,no significant mass effect.In 16 cases with Wernicke’s encephalopathy,there was a long T1 and long T2 signal symmetrically around the third ventricle,around the midbrain duct,and on both sides of the thalamic midbrain,and the water pressure image showed high signal.The diffusion image was diffused in 4 cases.Two cases of central pontine lysis of the parenchyma showed a long TI T2 signal in the pontine brain,a high signal in the water pressure image,and limited diffuse diffusion.In 16 patients with cerebral infarction,there was a low signal on T1 WI,a high signal on T2 WI and pressure water,and a blurred boundary.In 25 cases of degeneration of corpus callosum,the corpus callosum showed uniform or uneven T1 WI low signal,T2 WI hyperintensity,and T2 FLAIR hyperintensity,of which 3 cases had corpus callosum swelling,22 cases of corpus callosum atrophy,and 16 cases of DWI signal diffusion were limited.Among them,12 cases showed abnormal signals of long T1 and long T2 diffused in the corpus callosum;5 cases showed abnormally long T1 and long T2 signals in the corpus callosum;6 cases showed long T1 and long T2 signals in the corpus callosum.The FA value of the corpus callosum in the carcass of the patients with MBD was lower than that in the normal control group(P<0.01).The difference was statistically significant.The ADC values of carcass knees and compressions in patients with MBD were higher than those in the normal control group,and P<0.01.The difference was statistically significant.The body ADC value was less than the normal control group,P>0.01,the difference was not statistically significant.The MK values of the corpus callosum and body of MBD patients were lower than those of the normal control group,and the difference was statistically significant(P<0.01).The FA and MK values of patients with chronic alcoholism were significantly higher than those of the normal control group(P<0.01).According to the cut-off point of the largest Youdon index as the critical value,the study showed that the critical value of the FA value of MBD patients is 0.274,the sensitivity is 90.5%,the specificity is 72.9%,the AUG value is 0.852,and when 0.7-0.9,it means that Its diagnostic MBD performance is higher.According to the largest cut point of the Youdon index as the critical value,the critical value of the ADC value of MBD patients was 5.55,the specificity was 38.1%,the sensitivity was 89.6%,the AUG was 0.603,and the diagnostic MBD performance was 0.5-0.7.better.According to the cut-off point of the Youdon index as the critical value,the critical value of MK in patients with MBD was 0.874,the sensitivity was 85.7%,the specificity was 70.8%,and the AUG was 0.790.At 0.7-0.9,the diagnostic MBD performance was better.high.Conclusion The diagnostic value of FA value is better than that of ADC and MK.It has higher clinical significance in the diagnosis of carotid degeneration of chronic alcoholism.