Comparation Of Radiation And Corpus Callosum Between Anisometropic And Strabismus Amblyopia By Diffusion Tensor Imaging

Objective:Diffusion tensor imaging(DTI)was used to detect the development of optic radiation and corpus callosum in children with anisometropic and strabismic amblyopia.The differences in the mechanism of visual impairment between two different types of amblyopia were compared.Subjects and Method:Twelve children with anisometropic amblyopia(all left),12 children with strabismic amblyopia(all left),and 15 children with age-matched corrected visual acuity were scanned for DTI.The anisotropy fraction(FA)value and average diffusivity(MD)of the radiological and corpus callosum pressure components were analyzed for the single factor variance of the normal control group,the anisometropic amblyopia group,and the strabismic amblyopia group.The right and left side view radiation were paired t-tests,and the FA and MD values of the three groups of visual radiation and corpus callosum were analyzed by independent sample t-test.The development of visual radiation and corpus callosum in two types of amblyopic patients was analyzed and compared.Results: 1.Comparison of visual radiation: FA and MD of the normal control group were slightly higher on the right side than on the left side,and the differences were not statistically significant(P >0.05).The right side of the FA value of the anisometropic amblyopia group was high.On the left side,the right side of the MD value was lower than the left side,and the difference was statistically significant(P <0.05).Compared with the normal control group,the FA of both sides decreased and the MD increased,and the difference was statistically significant.(P <0.05);the right side of the FA value in the strabismic amblyopia group was lower than the left side,and the MD value was higher in the right side than the left side.The difference was statistically significant(P <0.05).Compared with the normal control group,the double The FA values of the lateral radiotherapy were all decreased,and the difference was statistically significant.The MD value of right-view radiation was higher than that of the normal control group.The difference was statistically significant(P <0.05).There was no significant difference in the left-view radiation MD value(P >0.05);Two types of amblyopia comparison: left-eye radiation FA values,MD values were statistically different,right-vision radiation FA values,MD values were not statistically different.2.Comparison of corpus callosum: There was no significant difference in FA value and MD between corpus callosum group and normal control group in anisometropic amblyopia group(P >0.05);FA value in strabismus group was lower than that in normal control group.Statistical significance(P <0.05).The MD value was higher than the normal group.The difference was not statistically significant.The FA value of the strabismic amblyopia group was lower than that of the anisometropic amblyopia group.The difference was statistically significant(P <0.05).The MD value was higher than that of the normal group and the difference was not statistically significant(P >0.05).Conclusion: 1.Anisometropic amblyopia is mainly manifested in poor development of amblyopic lateral radiation,and strabismic amblyopia is mainly manifested in contralateral visual radiation.It is inferred that there are differences in the microstructural changes of visual pathways of different types of amblyopia.2.The patients with strabismic amblyopia have worse corpus callosum development and stereo vision than those with anisometropia.It is speculated that the damage degree of stereopsis in different types of amblyopia may be related to the development of corpus callosum.