Clinical Value Assessment Of Retroperitoneal Lymphadenectomy In Malignant Ovarian Germ Cell Tumor

Objective:To explore the clinical value of retroperitoneal lymph node dissection in malignant ovarian germ cell tumor.Methods:A total of 295 clinical cases of malignant ovarian germ cell tumor which was from hunan cancer hospital from January 1,2004 to March 30,2018,were collected and divided into the study group(126 patients with MOGCT after retroperitoneal lymph node dissection)and the control group(169 patients with MOGCT without retroperitoneal lymph node dissection).In different pathological types,different FIGO stage,with fertility-sparing surgery and the adolescents and children,stratified analysis was performed to evaluate the clinical value of patients with MOGCT with retroperitoneal lymphadenectomy.All the data were statistically analyzed using SPSS 23.0,and the metering data were expressed by means of mean plus or minus standard deviation and the counting data was expressed in frequency(percentage).The chi-square test was used to compare the counting data.The survival curve was plotted using kaplan-meier method,and the survival analysis group was compared by log-rank method.p<0.05 was statistically significant.Results:1.In the patients with MOGCT with retroperitoneal lymph node dissection,statistical analysis showed significant difference by comparing the 5-year survival rate between patients with lymph node metastasis and patients with no lymph node metastasis in different pathological types(p=0.015)and the patients with FIGO stage I and II(p<0.01).2.In the patients with MOGCT with retroperitoneal lymph node dissection,we can see it was no significant different by analyzing the 5-year survival rate between patients with lymph node metastasis and patients without lymph node metastasis in middle and late FIGO stage(p=0.264),with fertility-sparing surgery(p=0.379)and adolescents or children(p=0.552).3.There was no statistically significant difference in the 5-year survival rate between MOGCT patients with retroperitoneal lymph node dissection and those without retroperitoneal lymph node resection.Conclusion:1.In different pathological(such as dysgerminoma,embryonal carcinoma and mixed MOGCT)and early(FIGO I-II)MOGCT patients,lymph node metastasis is a factor that reduce the survival rate,which means the retroperitoneal lymph node resection has clinical value.2.The lymph node metastasis rate of FIGO III MOGCT patients was the highest,but through the statistical analysis,FIGO III and middle and late stage(III-IV),the preservation of fertility function and the adolescent and children’s MOGCT patients,the lymph node metastasis is not a major factor affecting the survival rate,which means the retroperitoneal lymph node resection needs to be considered comprehensively.