Analysis Of Clinical And Prognosis In 18 Children Hemolytic Uremic Syndrome(HUS)

Objective: To explore the clinical features,treatment methods and prognostic factors of children hemolytic urine syndrome(HUS),and to improve the understanding of the clinical doctors.Methods: Analyzed retrospectively from 2007 to 2018 in jilin university first hospital,Bethune,a diagnosis of hemolysis uremic syndrome of 18 cases of hospitalized children with general information,clinical data,treatment and prognosis,and follow-up.Results: Among the 18 HUS patients,14 were male and 4 were female,with a ratio of 3.5 to 1,male is more than female.There were 14 cases of post-diarrhea HUS(D+HUS)in the 18 patients with HUS,and 14 patients with non-diarrhea HUS(D-HUS).The onset age ranged from 2 months to 12.3 years,and the number of children under 8 years old,it is distributed throughout the year,mainly in summer.The levels of lactate dehydrogenase and urea nitrogen in the D+HUS group were significantly higher than that in the D-HUS group,the levels of urine erythrocyte count,creatinine,total bilirubin,indirect bilirubin and direct bilirubin were significantly higher in the D-HUS group than in the D+HUS group,the proportion of complement C3 in group D-HUS was significantly higher than that in group D+HUS,but there was no statistically significant difference between the two groups.Only 1 of the 18 patients underwent genetic tests,and the results showed that CFHR1 and CFHR3 mutations were related to the incidence of HUS.The 18 HUS patients were treated with symptomatic and supportive treatment in the acute phase.Among them,6 patients were treated with plasma exchange,1 case was cured,4 cases were improved,1 was invalid,and 0 case died.There were 12 cases of untreated plasma replacement,0 case were cured,2 cases were improved,4 cases were invalid and 6 cases died.Compared with the prognosis of PE treatment group and non-PE treatment group,p<0.05,the difference was statistically significant,suggesting that the prognosis of PE treatment group was better than that of non-PE treatment group.Conclusion: 1.The male is more than female in HUS,the number of children under the age of 8,and more often in summer.2.Plasma exchange therapy for HUS patients can improve prognosis.3.The a HUS patients suggested genetic testing to further determine whether there was a gene mutation or gene mutation type.