Clinical Feature And Prognostic Of37Cases Of Children With Hemolytic Uremic Syndrome

Objective: To study clinical feature, laboratory examination,treatment and factors of prognosis of the hemolytic uremic syndrome(HUS)Methods: the clinical data of37children of HUS inpatient during1993-2013in our hospital were analysis retrospectively. Quantitative datawas expressed by mean+standard deviation (±SD) or median. T test orFishers exact probability method were performed when compared betweengroups. The prognosis factors were analyzed by Logistic regressionanalysis.Results:1. HUS was sporadic in Southwest China, children in ruralareas w, we found no epidemic outbreak and familial aggregation.2. HUS frequently occurred in children under6years old in spring andsummer.3.37children with HUS were divided into two groups, including thepost-diarrheal HUS (D+HUS) and the non-diarrheal HUS (D-HUS). D+HUS had12cases (32.43%), in which8patients received dialysistreatment. One case was developed to end stage renal disease within sixmonth later and died within1.5year. The mortality rate was8.33%; D-HUS had25cases (67.57%), in which15patients received dialysistreatment. One inpatient was died of Multiple organ failure. The mortalityrate was3.85%. The total mortality was5.41%.4. D-HUS was the main type of HUS in Southwest China. Therewere no difference with long-term prognosis between D-HUS and D+HUSgroups (P>0.05). D-HUS children are more likely to progress to ESRD inthe future.Conclusion: Children of HUS with oliguria for a long time have apoor prognosis and are more likely to develop ESRD in the future. Earlydiagnosis, early dialysis treatment is the key to reducing mortality.