Correlation Analysis Of Serum Osteocalcin Level And Insulin Resistance,Islet Beta Cell Function In Patients With Type 2 Diabetes Mellitus

Objective :To investigate the correlation between serum osteocalcin level and insulin resistance,islet beta cells in patients with type 2 diabetes mellitus.Methods :The study was conducted on 403 hospitalized patients with type 2 diabetes.Record their general information including gender,age,height,weight,medical history,etc.The levels of OC,Ca,Mg,P,PTH,25(OH)D,FBG,FINS,HbA1 c and 2hBG,2hINS after the glucose tolerance test were detected.Calculate their BMI,HOMA-IR,HOMA-β.The participants were grouped by age,sex,BMI and osteocalcin level to compare their metabolic status,according to the median level of osteocalcin in the study,the participants were divided into the low osteocalcin group(OL group,n= 201)and the high osteocalcin group(OH group,n= 202),then analyze the correlation between serum osteocalcin level and insulin resistance,islet beta cell function.Results:The level of Ca in the youth group was higher than that in the older group(P < 0.05).The level of oc(Z = 4.596,P< 0.001),PTH(Z =3.150,P= 0.002),P(t = 5.258,P< 0.001)were higher in the female group than those in the male group(P < 0.05).The level of 25(OH)D in the male group was higher than that in the female group(Z = 3.196,P= 0.001).And also the level of 25(OH)D in obese group was lower than that in overweight group and normal weight group(P< 0.05).The level of oc in overweight group was lower than that in normal weight group(P < 0.05).In OL group,HbA1c(t = 4.479,P< 0.001),FBG(Z = 3.579,P< 0.001),and 2hBG(Z = 4.413,P<0.001)were higher than those in OH group(P < 0.05).The 2hINS(Z = 3.482,P< 0.001),HOMA-β(Z = 2.397,P= 0.017)in OL group were lower than those in OH group(P <0.05).The level of oc was positively correlated with 2hINS(r = 0.152)and HOMA-β(r =0.121),but was negatively correlated with HbA1c(r =-0.244),FBG(r =-0.176),and2hBG(r=-0.241)(P < 0.001).Conclusion:The bone metabolic markers existed differences in patients with type 2 diabetes,there was significant correlation between serum OC and blood glucose metabolism,OC may participate in glycemic regulation by improving the function of islet beta cells and promoting insulin secretion.