Relationship Between Incremental Predictive Value Of Red Cell Distribution Width(RDW) And The TIMI Risk Score For 1year Clinical Outcome After St-elevation Myocardial Infarction(STEMI)

Objective: The incremental predictive value of red cell distribution width(RDW)for in hospital death and major adverse cardiacevents(MACEs)has not been fully investigated in patients with ST-elevation myocardial infarction(STEMI).Hypothesis:The aim of this study was to evaluate the relationship between red cell distribution width(RDW)and(the Thrombolysis in Myocardial Infarction(TIMI)risk score in patients with ST elevation myocardial infarction(STEMI).Methods: Between September 2011 and June 2016,453 patients with STEMI(372 male;mean age,57.7±11.7 years)were analyzed in this study.The influence of RDW and TIMI risk score to its 12 month cardiovascular disease mortality were observed.Results: 453 patients with STEMI,RDW of the death of(13.75±1.42)was significantly higher than that of the survivors(12.75±0.84),The differences were high statistically significant(P<0.001).Mortality of CVD was closely related with high TIMI score(HR=1.349,P<0.001),The New Model Group were significantly higher in patients with 1Year MACEs(P < 0.001).In a Cox proportional hazards model,RDW(hazard ratio [HR]: 1.426,P < 0.001)was an independentpredictor for 12-month MACEs.RDW as asingle risk factors added to the TIMI risk score,RDW was a high-risk early warning indicator of CVD indipendent of the other indicators of TIMI risk score.AUC of TIMI risk score was 0.707,RDW AUC was0.670,While the AUC of TIMI risk score combined with RDW(NEW MODEL GROUP)was 0.737.Kaplan-Meier survival analysis showed that the cumulative incidence of MACEs in the MODEL GROUP 3 was higher than that of patients in the MODEL GROUP 1,2,Increase with the degree of MODEL GROUP,The MACEs occurency was lifting.Conclusions: RDW level and TIMI risk score at admission has a similar predictivevalue to 1-year MACEs,TIMI risk score combined with RDW can improve the predictive value of 1-year MACEs in patients with STEMI,And it can be used for risk stratification in patients after admission.