Correlation Of Red Blood Cell Distribution Width With Acute ST-segment Elevation Myocardial Infarction Major Adverse Cardiac Events

ObjectiveExplore the correlation of the red blood cell distribution width with major cardiac events occurred during the period of hospitalization of acute ST-segment elevation myocardial infarction undergoing emergency PCI.MethodsA retrospective analysis of the patients hospitalized with acute ST-segment elevation myocardial infarction undergoing emergency PCI were collected from the database of the Second Affiliated Hospital of Zhejiang University School of Medicine between January2012and December2013. Collect its basic characteristics, metabolic biomarkers, cardiac ultrasound, blood and other indicators. A total of150patients with ASTEMI were included. The patients were categorized into2groups according to RDW(%)on admission:Higher RDW group≥13.5%and lower RDW group<13.5%. Two groups were compared using t test, ANOVA analysis, P<0.05for variables into the regression model, multivariate logistic regression analysis of independent predictors of major cardiac events and the receiver-operator characteristic (ROC) curve was drawn to evaluate the prognostic value of RDW on in-hospital mortality in patients with ASTEMI.ResultsThere was no significant difference between the two groups in terms of gender, smoking history, history of diabetes, hypertension and lipid levels, etc;(P>0.05). Higher group inflammatory markers CRP, creatinine, urea nitrogen, total plasma homocysteine were significantly increased, and there was statistically significant (P <0.05). Higher group Malignant arrhythmias, heart failure and shock incidence of death occur during hospitalization was significantly higher than lower group, and there is a statistically significant difference (P<0.05) groups. Area under curve was0.742, the best prognostic criteria for RDW on admission was13.5%, the sensitivity and specificity were72.7%and66.7%. RDW levels of ASTEMI patients were positively associated with major cardiac events risk. After adjustment for left atrial diameter、left ventricular ejection fraction、CRP levels、urea nitrogen, higher group entailed2.487times greater risk for major cardiac events than the lower group,(95%CI1.265±4.890, P<0.05).ConclusionPreoperative high levels of RDW is an independent predictor of major cardiac events occurred during the period of hospitalization of acute ST-segment myocardial infarction patients.