A Study On The Relationship Between Metabolic Syndrome And The Etiology,Malignancy And Prognosis Of Pancreatic Cancer

Objective:To investigate the relationship between metabolic syndrome and the etiology,malignancy and prognosis of the patients with pancreatic cancer.Methods: 395 patients with pancreatic cancer were collected from January,2013 to January,2018 in Qingdao Municipal Hospital,and 500 cases were selected randomly in the health database of the physical examination center.The age,height,gender,smoking history,drinking history,cholelithiasis history,history of cholecystectomy,chronic pancreatitis,history of chronic hepatitis B,body mass index,hyperglycemia,hypertension,hyperlipidemia,MS,pathological staging,differentiation degree,vessel invasion,nerve invasion and other related data were achieved from a retrospective analysis of the patient's medical records and health examination reports.According to the patients with or without pancreatic cancer,they were divided into two group,the group of the patients with pancreatic cancer and the patients without pancreatic cancer.According to the patients with pancreatic cancer complicated with or without MS,they were divided into two group,the group of the patients with pancreatic cancer complicated with MS and the patients with pancreatic cancer complicated without MS.Results: 395 patients with pancreatic cancer and 500 cases was selected,including 30 patients with pancreatic cancer complicated with MS and 365 patients with pancreatic cancer complicated without MS.The result of univariate analysis showed that the patients with pancreatic cancer have statistical difference in smoking history(P=0.015),cholelithiasis history(P=0.042),chronic pancreatitis(P=0.006),obesity(P<0.001),high glucose(P<0.001),hypertension(P=0.029),high cholesterol(P<0.001),MS(P<0.001)compared with those of the individual cases.The patients with pancreatic cancer have significant statistical difference in chronic pancreatitis,abdominal obesity,high blood sugar,high blood lipids,MS compared with those of the individual cases.The result of multivariate analysis showed that the history of chronic pancreatitis(P=0.02,OR=3.192),obesity(P=0.049,OR=1.383),hyperglycemia(P=0.033,OR=1.732),MS(P=0.046,OR=2.803)were the independent factors affecting the etiology of pancreatic cancer.The pathological staging of pancreatic cancer was statistically difference(P=0.036)in the patients with pancreatic cancer complicated with MS and the patients with pancreatic cancer without MS.The differentiation degree of pancreatic cancer was not statistically difference(P=0.357)in the patients with pancreatic cancer complicated with MS and the patients with pancreatic cancer complicated without MS.The patients with pancreatic cancer complicated with MS have not significant statistical difference in vessel invasion(P=0.030)and nerve invasion(P=0.023)compared with those of the patients with pancreatic cancer complicated without MS.Conclusions: Smoking history,history of cholelithiasis,history of chronic pancreatitis,obesity,hyperglycemia,hypertension and hyperlipidemia are associated with pancreatic cancer.The history of chronic pancreatitis,obesity,hyperglycemia,hyper lipidemia,and MS were closely related to the etiology of pancreatic cancer.The history of chronic pancreatitis,obesity,hyperglycemia,and MS are the independent factors affecting the etiology of pancreatic cancer.Pancreatic cancer complicated with MS may indicate a higher degree of malignancy.There is no correlation between pancreatic cancer complicated with MS and pancreatic cancer complicated without MS in differentiation,there is a certain correlation in vessel invasion and nerve invasion between pancreatic cancer complicated with MS and pancreatic cancer complicated without MS.The relationship between the prognosis of pancreatic cancer with MS and that of pancreatic cancer without MS is not clear.