Relationship Between Staphylococcus Aureus Colonization And Infection After Total Knee Arthroplasty

Objective: Staphylococcus aureus has become one of the more common pathogenic bacteria species in joint surgery.It poses a major problem in clinical treatment and prevention of infection.Surgical site infections caused by Staphylococcus aureus in orthopedic and joint surgery The infection SSI)as well as many problems that have been caused have been persistently and increasingly aggravated.As an important factor in the infection after artificial joint replacement,it is also an enormous challenge faced by orthopedists.Staphylococcus aureus SAU has become one of the major pathogens of postoperative infection in major hospitals around the world [1] over the past few decades.The most common pathogen for infections after total knee arthroplasty is SAU,which accounts for approximately 63%,and includes methicillin-sensitive Staphylococcus aureus(MSSA),methicillin-resistant Staphylococcus aureus(MRSA),and coagulase-negative staphylococci[1].Studies have shown that intranasal colonization of bacteria affects the postoperative infection rate in patients with joint replacement,while Staphylococcus aureus is one of the most common colonization bacteria in the nasal cavity,however,both at home and abroad for the discussion of colonization rate of Staphylococcus aureus in the nasal cavity on the whole knee Whether there is a certain influence on postoperative infection in joint replacement patients is less researched.Given that surgical site infections caused by Staphylococcus aureus account for >60% of total knee arthroplasty and hip replacement postoperative infections,infection prevention and control strategies are important pillars to optimize patient safety and reduce economic losses,so study nasal cavity The SAU colonization rate and the infection rate after total knee arthroplastyhave important clinical value.In this study,patients undergoing total knee arthroplasty were preoperatively monitored for colonization of Staphylococcus aureus in the nasal cavity,and early postoperative infections were followed.Statistical analysis was performed to investigate the infection after total knee arthroplasty and in the nasal cavity.The relevance of SAU colonization rate was used to understand the impact of colonization rate of Staphylococcus aureus on total knee arthroplasty surgery infection and provide reference for clinical work.Methods: From October 2016 to August 2017,a total of 200 patients who underwent knee joint replacement were included.Among them,76(38%)were males and 124(62%)were females.The general data of registered patients included,age,gender,presence of diabetes,BMI index.Surgical patients were collected preoperatively for prenasal bacterial samples and cultured to detect SAU colonization rates.All patients were followed for an average of 6 months after surgery.The postoperative infections were recorded and the infection rate was recorded.SPSS19.0 software was used to perform statistical analysis on each data.General data were collected as measurement and counting statistics.Logistic regression was used to predict the correlation between general data and SAU detection rate,and the follow-up results of postoperative infections were carded.Party test.Results: A total of 69 patients with elective TKA were enrolled in the nasal vestibule and tested for positive SAU colonization;the patient's gender,age,and BMI were not associated with preoperative nasal SAU colonization(P > 0.05);Diabetes was associated with preoperative nasal SAU colonization(P<0.05).In the 6-month postoperative follow-up,there was a statistically significant difference between the SAU-positive group and the negative group(P<0.05).Conclusions: There is a correlation between preoperative and postoperative SAU colonization rates in patients undergoing total knee arthroplasty for total knee arthroplasty;positive and negative SAU colonization tests before total knee arthroplasty have a significant incidence of infection during follow-up.Sexual differences.