The Correlation Between Serum Haptoglobin,Neuron-specific Enolase And The Neuron Injury And Prognosis Of Acute Cerebral Infarction

Objective:To investigate the correlation between the levels of serum haptoglobin combined with neuron-specific enolase and the neuron injury as well as the prognosis of the patients with acute cerebral infarction.Methods:We selected 102 hospitalized patients with acute cerebral infarction in our department of neurology from December 2016 to December 2017,which was regarded as the acute cerebral infarction group.During hospitalization,all acute cerebral infarction patients underwent head imaging.The volume of the infarcted lesions in the acute cerebral infarction group was calculated according to the Tada formula(V=?/6 × maximal infarct cross-sectional length × best infarct cross-section × thickness)and grouped(V<5cDm3 for small volume,5<V<10 cm3 for medium volume,V?10 cm3 is large volume).The modified Rankin Score was used to evaluate the recovery of neurological function after 14 days of onset of disease and all patients were grouped according to scores:better prognosis group(0-1 points)and poor prognosis group(2-6 points).In the same period of time,81 cases of previous cerebral infarction in our department were the old cerebral infarction group.At the same time,97 physical examination volunteers of different ages and genders in the physical examination center of our hospital at the same time were selected as the control group.Enzyme-Linked Immunosorbent Assay was used to measure the serum haptoglobin,neuron-specific enolase concentrations of the subjects.The differences between the groups were compared and the correlation between haptoglobin and neuron-specific enolase levels was analyzed.Results:1.Serum haptoglobin levels in the acute cerebral infarction group were significantly higher than those in the old cerebral infarction group and the control group.There was no significant difference in serum haptoglobin levels between the old cerebral infarction group and the control group.2.Serum neuron-specific enolase levels in the acute cerebral infarction group were significantly higher than those in the old cerebral infarction group and the control group.There was no significant difference in serum neuron-specific enolase levels between the old cerebral infarction group and the control group.3.In the acute cerebral infarction group,the levels of serum haptoglobin in the middle infarct group and the large infarct group were higher than in the small infarct group,while the middle infarct group was similar to the large infarct group.Further Spearman rank correlation analysis showed that the levels of serum haptoglobin in the acute cerebral infarction group was positively correlated with the infarct volume.4.In the acute cerebral infarction group,the levels of serum neuron-specific enolase in the small infarct group and the middle infarct group were lower than in the large infarct group,while the small infarct group was similar to the middle infarct group.Further Spearman rank correlation analysis showed that the levels of serum neuron-specific enolase in the acute cerebral infarction group was positively correlated with the infarct volume.5.The serum levels of haptoglobin and neuron-specific enolase in the acute cerebral infarction group were linearly correlated.6.In the acute cerebral infarction group,the serum haptoglobin levels in the poor prognosis group were significant higher than those in the better prognosis group.7.In the acute cerebral infarction group,the serum neuron-specific enolase levels in the poor prognosis group were higher than those in the better prognosis group.Conclusion:Serum haptoglobin,neuron-specific enolase levels have a certain correlation with the degree of the neuron injury and prognosis of patients with acute cerebral infarction.