Effect Of Cyclosporin A Combined With Fluconazole On Conditional Infection Of Candida Albicans

Objective: To investigate the effect of cyclosporine A on the Candida albicans through FLC,and to provide reference for random infections represented by Candida albicans.Methods: a.40 mice were selected and divided into Candida group,Candida+FLC group,Candida +FLC+CSA group,and control group,10 in each group.b.Mice were intraperitoneally injected with 1 ml Candida albicans suspension + physiological saline mixture(Candida albicans suspension: Saline=0.5ml : 0.5ml)for 10 consecutive days.c.Cyclosporin A was formulated as a 1.5 mg/ml solution by Olive oil,each mouse was intragastrically administered at 1 ml/d,while FLC was intragastrically administered at 1 ml/d.d.Each mouse was fed with a single cage,and the water intake,food intake,excretion,body weight change,blood glucose,and body temperature of each mouse were observed for one week,and TNF-? and IFN-? were measured by ELISA.Results: The effect of cyclosporin A combined with FLC on TNF-? was significant.It could reduce the level of inflammatory factor IFN-? and improve the inflammation.Over time,the combined use of CSA and FLC to improve the water intake,food intake,and excretion of mice infected with Candida albicans has become more and more significant.The body weight of mice has also changed significantly,but the effect on blood glucose and body temperature is not affected obviouslly.Conclusions: The combination of CSA and FLC can improve the symptoms of Candida albicans-infected mice,and it is of great significance for the prevention of immunodeficiency represented by Candida albicans of opportunistic infections under immunodeficiency or low status.CSA is relatively safe and has little effect on metabolic parameters such as blood glucose and body temperature.