Relationship Between Thyroid Function,Autoantibodies And Acute Cerebral Infarction

Objective:By observing the changes of thyroid function and autoantibodies in patients with acute cerebral infarction,the clinical significance of thyroid dysfunction and its autoantibodies in patients with acute cerebral infarction and necrosis was explored.Methods:Through the use of Neusoft electronic medical record system and Uritest electronic medical records system,information of patients with cerebral infarction who had an attack no more than 1 week ago from January 2017 to January 2018 in the neurology department of Affiliated Hospital of Guilin Medical College were collected retrospectively.By detailed inquiry of patient's history of smoking and drinking based on their personal medical history,and thorough biochemical and serological examination,neck vascular ultrasound?including carotid artery and vertebral artery color ultrasound,intracranial and cervical Doppler ultrasound,magnetic resonance MRA,cervical CTA,total cerebral angiography?and so on,201 cases of acute cerebral infarction patients were divided into clinical hyperthyroidism and subclinical hyperthyroidism group,hypothyroidism group which include clinical hypothyroidism and subclinical hypothyroidism,and normal thyroid function group according to their thyroid function and antibodies result.Using statistical methods,demographic of each group,risk factors of cerebral infarction,other biochemical indexes?blood lipid composition,HCY,fasting plasma glucose?,and the correlation of neck vascular atherosclerosis were compared and analyzed.Based on patients' NIHSS score,they were divided into mild stroke,moderate stroke and severe stroke.According the difference of patients' vascular examination,assessment of patients with or without vascular stenosis.The relationship between thyroid hormone level and autoantibody with acute cerebral infarction?ACI?was observed and analyzed.Results:Among 201 patients,131 were male and 70 were female.There were 53 patients with abnormal thyroid function,25 patients with hypothyroidism,28 patients with hyperthyroidism and 148 patients with normal thyroid function.In patients with acute cerebral infarction,the incidence of atrial fibrillation in hyperthyroidism group was significantly higher than that in other groups?P<0.05?.There was no obvious difference in hypertension,diabetes,blood pressure,fasting blood glucose,blood lipid composition and blood homocysteine between thyroid group and other groups.In different NIHSS groups,it was found that with the increase of NIHSS score,FT₃ gradually decreased,TSH gradually increased,but thyroid autoantibodies had no statistical significance.And there was a significant statistical difference between FT₃,TSH and the severity of acute cerebral infarction?P<0.01?.In patients with acute cerebral infarction less than60 years old,There was significant statistical difference between TSH and A-TPO level and intracranial vascular stenosis?P<0.05?.Conclusions:Thyroid dysfunction is associated with atrial fibrillation,which suggests that thyroid dysfunction may be a risk factor for acute cerebral infarction.With the increase of NIHSS score,FT₃ decreased gradually,suggesting that the decrease of thyroid function might be helpful to evaluate the severity of acute cerebral infarction.In young and middle-aged patients,TSH and A-TPO were associated with cerebrovascular stenosis.