Association Of Erythrocyte Parameters With Metabolic Syndrome And It's Components Among Community Medical Examination Population

ObjectivesThe aims of this study were to assess the prevalence of Metabolic Syndrome(MetS)and its components among community medical examination population;to explore the distribution and combination of components among patients with MetS;to analyze the association of erythrocyte parameters with the number of MetS components;and to investigate the association of erythrocyte parameters with MetS and its components stratified by sex.MethodsIn this cross-sectional study,we collected medical examination information from community residents in the Pearl River Delta in 2015.According to inclusion and exclusion criteria,a total of 4672 subjects were enrolled in the study.The contents of this study included: demographic characteristics(age,gender),history of diseases(cardiovascular diseases,liver diseases,kidney diseases,benign or malignant tumors,acute or chronic inflammation),anthropometric parameters(height,weight,waist circumference [WC],systolic blood pressure [SBP],diastolic blood pressure [DBP]),and laboratory tests.laboratory tests include four lipids(triglyceride [TG],total cholesterol [TC],high-density lipoprotein cholesterol [HDL-C],low-density lipoprotein cholesterol [HDL-C]),fasting plasma glucose[FPG],uric acid [UA],blood routins(white blood cell [WBC] count,platelets [PLT],hematocrit [HCT],hemoglobin [Hb],red blood cell [RBC] count,red cell distribution Width [RDW]),liver functions(alanine aminotransferase [ALT],aspartate aminotransferase [AST],?-glutamyl transpeptidase [GGT],albumin [ALB]),glycated hemoglobin A1 c [HbA1c]).MetS was diagnosed using a modified version of the National Cholesterol Education Program,Adult Treatment Panel ?(NCEP,ATP?)criteria(2005).EpiData 3.1 was used to establish the database,and data was analyzed by using SPSS21.0.The statistical methods of this study included descriptive analyses(mean,standard deviation,frequency,percentage),independent sample t-test,Chi-square test,one way ANOVA,univariate and multivariate Logistic regression analyses.Data was analyzed with a P value <0.05 regarded as the significant level.in this study(two-tailed).Results1.A total of 4672 individuals were included in the study,of which 2161 were males(46.3%)and 2511 were females(53.7%).The mean age of the partocopants was 55.57 ± 13.27 years,of which 53.75 ± 13.46 years for males and 57.14 ± 12.90 years for females(P <0.05).2.In the basic data,except for HDL-C,ALB,TC,LDL-C and PLT,the levels of other parameters among males were higher than that of among females.In the cluster of MetS components,differences between genders were clearly significant considering WC,DBP,TG,HDL-C and FPG levels(P<0.05).In the cluster of erythrocyte parameters,except for RDW,differences between genders were clearly significant in terms of others' parameters(P<0.05)3.The overall prevalence of MetS in this study was 31.3%,and females had a higher prevalence than that in males(26.7% VS 35.2%,P <0.05).The prevalence of MetS in males aged 18~45 years was significantly higher than that in females(29,8% VS 24.3%,P <0.05),however,the prevalence of MetS in females aged ?60 years was significantly higher than that in males(41.2% VS 19.1%,P <0.05).4.The prevalence of MetS components in this population was as follows: hypertension(60.7%),central obesity(42.7%),low HDL-C(41.0%),high TG(29.0%),high FPG(15.9%).5.The prevalence of hypertension and low HDL-C in patients with MetS was the highest(83.2%),followed by central obesity and high TG.There was a total of 16 combinations of MetS components in patients with MetS,the top three combinations were central obesity + hypertension + high TG + low HDL-C,central obesity + hypertension + low HDL-C and hypertension + high TG + low HDL-C.6.The average levels of HCT,Hb,RBCand RDW in the study were positively associated with the increasing number of MetS componentsin bothmales and females(P<0.05).7.In males,the prevalence of central obesity,hypertension,high TG and low HDL-C increased with the increase of Hb,HCT and RBClevels(P<0.05).In females,the prevalence of central obesity,hypertension,high TG and low HDL-C greatly increased with the increase of HCT,Hb,RBC and RDW levels(P<0.05).8.Multivariate logistic regression analysis: Hb was associated with the risk of MetS in both genders(males,Q2: OR=1.921,95%CI=1.170 to 3.151;Q3: OR=1.992,95%CI=1.198~3.312;females,Q2: OR=1.538,95%CI=1.008 to 2.348;Q3: OR=1.665,95%CI=1.075 to 2.578),however,RDW was only related to the risk of MetS in males(Q3: OR=2.725,95%CI=1.915 to 3.878),RBC was only correlated with the risk of MetS in females(Q3:OR=1.718,95%CI=1.173 to 2.515).Conclusions1.The overall prevalence of MetS among community residents in the Pearl River Delta was 31.3%,and females had a higher prevalence than that in males;The prevalence of MetS in males aged 18~45 years was significantly higher than that in females,however,the prevalence of MetS in females aged ?60 years was significantly higher than that in males.Among the components of MetS,the prevalence of hypertension was the highest.2.Hypertension and low HDL-C occurred most frequently in patients with MetS;Hypertension,dyslipidemia and central obesity play an important role in the development of MetS.3.The mean levels of erythrocyte parameters were positively associated with the increasing numbers of MetS components.4.The prevalence of central obesity,hypertension and dyslipidemia was positively correlated with the increase of HCT,Hb and RBClevels in both males and females.Of the four erythrocyte parameters,Hb was associated with the risk of MetS in both genders,but RDW was only related to the risk of MetS in males,and RBC was only correlated with the risk of MetS in females.