Alcoholicliver Disesase Injury Model Study Using Jiu Dan

Objective:To observe the changes of behavior,liver function,antioxidant index and liver histopathology in rats with acute and chronic alcoholic liver injury.Explore the protective effect and mechanism of action of Self-made prescription under different combination forms to alcohol-induced liver injury model rat.Method:Wistar rats were divided into blank group?model group the whole recipe group and disassembled formulas group.In addition to the blank group and the model group,the other 4 groups were given the prescribed dose for each group.After 30min,the ethanol solution of 56%in the concentration of alcohol was administered to the mice.The mice model of acute alcoholism was replicated.After the successful replication of the model,the difference of behavior and the change of the concentration of serum ethanol in the mice were detected.Results:1.By behavior in mice model of acute alcohol intoxication and alcohol concentration study found that:compared with model group,the whole party group,the desuperheating in group with significant statistical difference.2.By the rat model of chronic alcoholic liver damage the liver index and liver tissue pathologic morphology,biochemistry index,anti-oxidation index research found that:compared with model group,the whole party group,reduction temperature,reduce flower of kudzuvine group with significant statistical difference.3.By the rat model of chronic alcoholic liver damage of alcohol dehydrogenase study found that:compared with model group,the whole party group,the spleen group,and temperature reduction in group with statistical significance.Conclusion:1.The original party group can increase the alcohol metabolism rate of acute alcoholism mice,the drunk,autonomous activity of acute alcoholism mice a number increase,balance error number increase,learning skills,can choose flos puerariae solution arouse arouse soup soup of the original party or flos puerariae solution temperature reduction in groups.2.When the hepatic index is enlarged,the liver tissue can be selected by either the original group or the reduction group.3.In the treatment of alcoholic liver injury caused by AST,ALT,TBIL,TG rise,shall be made in flower of kudzuvine gentleman medicine on the basis of discretionary USES and qi,spleen group,the compatibility of water group,in order to highlight its descending transaminase,lipid-lowering effect.4.In the case of the change of antioxidant index in the case of alcoholic liver injury,the combination of the healthy spleen group,the rational gas group and the lishui group should be used on the basis of the drug.5.Flos puerariae has effects on the increase of alcohol dehydrogenase,and flower of kudzuvine to alcohol in the body's metabolic process played an important role in promoting decomposition,choose in clinical flower of kudzuvine for gentleman medicine compatibility,such as used in the treatment of acute alcohol poisoning alcohol metabolism diseases.