Association Between 8q24 Gene Polymorphisms And Prostate Cancer In Anhui Population

Objective Many studies have identified multiple single nucleotide polymorphisms(SNPs)on 8q24 associated with prostate cancer(PCa)risk in recent years,This study aims to determine whether two SNPs,rs10090154 and rs16901966 on chromosome8q24,were associated with PCa risk in Anhui population.Methods We conducted a case-control study comprising of 90 prostate patients and 139 healthy controls.The rs10090154 and rs16901966 polymorphism on 8q24 was determined by Mass ARRAY DNA genotyping method.The association between genotype and risk of PCa,stratified by age,body mass index(BMI),systolic blood pressure(SBP),clinical stages,gleason grades and prostate-specific antigen(PSA)values were also determined.Results The genotypes and allelic frequencies of 8q24 rs10090154 and rs16901966 on8q24 were significantly different between case and control group.In the hierarchical analysis,the analysis demonstrated that variant genotypes CT/TT in rs10090154 were associated with an increased risk of PCa in subjects age?70 years(P=0.002,OR=3.814,95%CI:1.634~8.901),BMI>23kg/m2(P=0.001,OR=3.449,95%CI:1.629~7.303),SBP?140mm Hg(P=0.008,OR=3.148,95%CI:1.352-7.328)relative to those with the CC genotype and variant genotypes AG/GG in rs16901966 offered an increased risk of PCa in subjects age >70years(P=0.024,OR=2.567,95%CI:1.132~5.818),BMI>23kg/m2(P=0.029,OR=2.030,95%CI:1.074~3.838)relative to those with the AA genotype.In addition,no significant associations were observed in patients with different clinical stages or Gleason grades and PSA values.Conclusion our work demonstrates that rs10090154 and rs16901966 polymorphism on8q24 may offer an increased risk of PCa in Anhui population.