The Influence Of Sleep Quality On The Levels Of Systemic Inflammatory Medium In Patients With COPD And The Correlations Between The Frequency Of AECOPD And Pittsburgh Sleep Quality Index

Objective This study is aimed to investigate the influence of sleep quality on the levels of systemic inflammatory medium in patients with COPD and the correlations between the frequency of AECOPD and Pittsburgh sleep quality index.Methods Collected 198 cases of COPD patients who were treated in our hospital from October,2016 to June,2017.124 of 198 cases were eligible.On the first day of hospitalization,the serum samples and clinical data were collected,such as,white blood cells,Neutrophils,lymphocytes,platelet count,CRP and PSQI.Poor sleep quality was defined as Pittsburgh Sleep Quality Index score >5.Results The incidence of COPD patients with poor sleep quality was about 68%.Poor sleep quality was positively correlated with the frequency of acute exacerbation in COPD patients.The ratio neutrophil to lymphocyte(NLR),ratio platelet to lymphocyte(PLR)and levels of CRP were also higher than the control group.NLR,PLR and CRP in peripheral blood of the patients with poor sleep quality were positively correlated with PSQI score.The CRP levels and PSQI score in COPD patients with poor sleep quality group were positively correlated with the frequency of exacerbations in the past year(r=0.437,r=0.430).Conclusion: COPD patients often have higher incidence of poor sleep quality,which is positively correlated with the levels of systemic inflammation as well as the frequency of AECOPD.